Sensation, movement and learning in the absence of barrel cortex.
Sensation, movement and learning in the absence of barrel cortex.
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DOI：
10.1038/s41586-018-0527-y
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发表时间：
2018-09
期刊：
影响因子：
64.8
通讯作者：
Bruno RM
中科院分区：
文献类型：
--
作者：
Hong YK;Lacefield CO;Rodgers CC;Bruno RM
对于我们的许多感官来说，大脑皮层在检测刺激方面的作用是有争议的。在这里，我们研究了初级体感皮层（S1）的急性和慢性失活对小鼠的影响，这些小鼠经过训练，可以移动它们的大面部胡须，通过触摸来探测物体，并用杠杆做出反应，以获得水奖励。利用转基因动物，我们在兴奋性皮质神经元中表达了抑制性视蛋白。S1的瞬时光遗传失活以及永久性病变最初会产生运动和感觉缺陷，从而损害检测行为，这表明在主动感知过程中感觉和运动系统之间存在不可分割的联系。令人惊讶的是，受损小鼠在随后的实验中迅速恢复了全部的行为能力。恢复是经验依赖的，损伤后早期重新接触任务有助于恢复。此外，学习前初级感觉皮质消融不影响任务习得。这种结合光遗传学和损伤的方法表明，对感觉皮层的操纵可能只是暂时破坏其他大脑结构，这些大脑结构本身能够协调多种任意运动和感觉。因此，体感皮层对于环境中物体的主动检测可能是可有可无的。
For many of our senses, the role of the cerebral cortex in detecting stimuli is controversial. Here, we examine the effects of both acute and chronic inactivation of primary somatosensory cortex (S1) in mice trained to move their large facial whiskers to detect an object via touch and respond with a lever to obtain a water reward. Using transgenic animals, we expressed inhibitory opsins in excitatory cortical neurons. Transient optogenetic inactivation of S1, as well as permanent lesions, initially produced both movement and sensory deficits that impaired detection behavior, demonstrating the inextricable link between sensory and motor systems during active sensing. Surprisingly, lesioned mice rapidly recovered full behavioral capabilities by the subsequent session. Recovery was experience-dependent, and early re-exposure to the task after lesion facilitated recovery. Furthermore, primary sensory cortex ablation prior to learning did not affect task acquisition. This combined optogenetic and lesion approach suggests that manipulations of sensory cortex may be only temporarily disruptive to other brain structures, which are themselves capable of coordinating multiple, arbitrary movements with sensation. Thus, the somatosensory cortex may be dispensable for active detection of objects in the environment.
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影响因子：
16.2
作者：
Hill DN;Curtis JC;Moore JD;Kleinfeld D
通讯作者：
Kleinfeld D
影响因子：
3
作者：
Oliveira-Maia AJ;de Araujo IE;Monteiro C;Workman V;Galhardo V;Nicolelis MA
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Nicolelis MA
影响因子：
5.3
作者：
Cohen, Jeremy D.;Castro-Alamancos, Manuel A.
通讯作者：
Castro-Alamancos, Manuel A.
影响因子：
5.3
作者：
Pammer, Lorenz;O'Connor, Daniel H.;Svoboda, Karel
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Svoboda, Karel
由行为相关性驱动的听觉皮层中的灵活感觉表示。
影响因子：
16.2
作者：
Kato HK;Gillet SN;Isaacson JS
通讯作者：
Isaacson JS