Enhancement of aerobic fitness improves social functioning in individuals with schizophrenia.
Enhancement of aerobic fitness improves social functioning in individuals with schizophrenia.
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DOI：
10.1007/s00406-020-01220-0
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发表时间：
2021-03
影响因子：
4.7
通讯作者：
Bartels MN
中科院分区：
文献类型：
--
作者：
Kimhy D;Tay C;Vakhrusheva J;Beck-Felts K;Ospina LH;Ifrah C;Parvaz M;Gross JJ;Bartels MN
精神分裂症患者在社会功能(SF)方面表现出严重的缺陷，其特征是慢性、终身的表现。然而，目前很少有有效的干预措施来提高这一人群的SF。来自临床人群研究的新证据显示，类似的SF缺陷表明，有氧运动(AE)可能会提高社交技能。然而，这种假定的影响还没有在精神分裂症中进行调查。采用单盲随机临床试验设计，33名精神分裂症患者随机接受为期12周的照常治疗(TAU；n = 17)或TAU + AE(n = 16)，使用主动玩视频游戏(Xbox360Kinect)和传统的AE设备。参与者在基线和12周后完成了有氧健身(VO2max)以及自我、告密者和临床医生报告的SF测量的评估。26名参与者完成了这项研究(79%；TAU = 13；AE = 13)。在随访中，AE参与者的最大摄氧量提高了18.0%，而对照组的− 提高了0.5%(x次互动组，F1，24 = 12.88；p = .002)。分级逐步回归分析表明，VO2max的改善显著地预测了SF的改善，根据自我、告密者和临床医生报告的指标，分别预测了47%、33%和25%的变异(控制了基线人口统计学、药物、情绪症状和社会网络)。与TAU组相比，AE参与者报告的SF显著改善(23.0%比− 4.2%；组 × 时间交互作用，F1，24 = 7.48，p = .012)。结果表明，最大摄氧量增加导致精神分裂症患者SF的改善。此外，低VO2max代表了精神分裂症患者SF的一个可改变的危险因素，对于这种情况，AE训练提供了一种安全、非污名化和几乎无副作用的干预措施。
Individuals with schizophrenia display substantial deficits in social functioning (SF), characterized by chronic, lifelong presentations. Yet, at present there are few effective interventions to enhance SF in this population. Emerging evidence from studies of clinical populations that display similar SF deficits suggests that aerobic exercise (AE) may improve social skills. However, this putative impact has not been investigated in schizophrenia. Employing a single-blind, randomized clinical trial design, 33 individuals with schizophrenia were randomized to receive 12 weeks of Treatment-As-Usual (TAU; n = 17) or TAU + AE (n = 16) utilizing active-play video games (Xbox 360 Kinect) and traditional AE equipment. Participants completed an evaluation of aerobic fitness (VO2max) as well as self-, informant-, and clinician-reported SF measures at baseline and after 12 weeks. Twenty-six participants completed the study (79%; TAU = 13; AE = 13). At follow-up, the AE participants improved their VO2max by 18.0% versus − 0.5% in the controls (group x time interaction, F1,24 = 12.88; p = .002). Hierarchical stepwise regression analyses indicated improvements in VO2max significantly predicted enhancement in SF as indexed by self-, informant-, and clinician-reported measures, predicting 47%, 33%, and 25% of the variance, respectively (controlling for baseline demographics, medications, mood symptoms, and social networks). Compared to the TAU group, AE participants reported significant improvement in SF (23.0% vs. − 4.2%; group × time interaction, F1,24 = 7.48, p = .012). The results indicate that VO2max enhancement leads to improvements in SF in people with schizophrenia. Furthermore, low VO2max represents a modifiable risk factor of SF in people with schizophrenia, for which AE training offers a safe, non-stigmatizing, and nearly side-effect-free intervention.
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精神分裂症患者的情绪低落：回顾性和实时措施的比较。
影响因子：
11.3
作者：
Blum, Lisa H.;Vakhrusheva, Julia;Saperstein, Alice;Khan, Samira;Chang, Rachel W.;Hansen, Marie C.;Zemon, Vance;Kimhy, David
通讯作者：
Kimhy, David
影响因子：
6.6
作者：
Firth J;Stubbs B;Rosenbaum S;Vancampfort D;Malchow B;Schuch F;Elliott R;Nuechterlein KH;Yung AR
通讯作者：
Yung AR
DOI：
10.1192/bjp.bp.111.105700
发表时间：
2013-01
期刊：
The British journal of psychiatry : the journal of mental science
影响因子：
--
作者：
Brambilla P;Perlini C;Rajagopalan P;Saharan P;Rambaldelli G;Bellani M;Dusi N;Cerini R;Pozzi Mucelli R;Tansella M;Thompson PM
通讯作者：
Thompson PM
影响因子：
2.3
作者：
Huprich, SK;Sanford, K;Smith, M
通讯作者：
Smith, M
影响因子：
6.6
作者：
Couture, Shannon M.;Penn, David L.;Roberts, David L.
通讯作者：
Roberts, David L.