Schizophrenia severity, social functioning and hippocampal neuroanatomy: three-dimensional mapping study.
Schizophrenia severity, social functioning and hippocampal neuroanatomy: three-dimensional mapping study.
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DOI：
10.1192/bjp.bp.111.105700
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发表时间：
2013-01
期刊：
影响因子：
--
通讯作者：
Thompson PM
中科院分区：
文献类型：
--
作者：
Brambilla P;Perlini C;Rajagopalan P;Saharan P;Rambaldelli G;Bellani M;Dusi N;Cerini R;Pozzi Mucelli R;Tansella M;Thompson PM
海马体萎缩是精神分裂症的常见报告，但它在疾病中的作用仍然知之甚少。特别是，目前还不清楚临床和心理社会变量如何与海马体体积相关。为了解决这一问题，三维(3-D)计算图像分析的新方法可能提供比标准体积测量更详细的神经解剖学差异研究。我们使用高分辨率磁共振成像和基于表面的建模来绘制海马区差异的3D轮廓。海马体的三维参数化网格模型是通过手动跟踪创建的。回归模型被用来将诊断措施与径向距离图联系起来。生成了颜色编码的地图以显示关联的概况。67例成人精神分裂症患者(平均年龄39.40±12.08岁；男44例，女23例)和72例健康对照(平均年龄39.28±11.03岁，男38例，女34例)。精神分裂症患者和对照组之间的海马径向距离无明显差异。然而，在患者中，双侧萎缩与更严重的疾病(即疾病持续时间、阳性和阴性症状)和较差的社会功能(即教育水平、生活质量和健康状况)有关，这些都在Bonferroni矫正后存活。疾病严重程度和社会功能不良可能与精神分裂症患者的海马体萎缩有关。作为预后不良的结构性迹象，成像措施可能有助于识别可能需要特定治疗以抵抗海马体体积减少的患者亚群，如认知康复或体育锻炼。
Hippocampal shrinkage is commonly reported in schizophrenia, but its role in the illness is still poorly understood. In particular, it is unclear how clinical and psychosocial variables relate to hippocampal volumes. To address this, new methods for three-dimensional (3-D) computational image analysis may offer more detailed investigation of neuroanatomic differences than standard volumetric measures. We used high-resolution magnetic resonance imaging and surface-based modeling to map the 3D profile of hippocampal differences. 3D parametric mesh models of the hippocampus were created from manual tracings. Regression models were used to relate diagnostic measures to maps of radial distance. Color-coded maps were generated to show the profile of associations. 67 adults with schizophrenia (mean age= 39.40±12.08 years; 44 males/23 females) and 72 healthy controls (mean age= 39.28±11.03 years; 38 males/34 females). There were no detectable differences in hippocampal radial distance between schizophrenia patients and controls. In patients, however, bilateral shrinkage was associated with greater illness severity (i.e. length of illness, positive and negative symptoms), and with poorer social functioning (i.e. educational level, quality of life and health status), which survived Bonferroni correction. Illness severity and poor social functioning may be associated with hippocampal shrinkage in schizophrenia. As a structural sign of poor outcome, imaging measures may help to identify a subgroup of patients who may need specific treatment to resist hippocampal decreased volumes, such as cognitive rehabilitation, or physical exercise.
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影响因子：
4.5
作者：
Baiano, Monica;Perlini, Cinzia;Brambilla, Paolo
通讯作者：
Brambilla, Paolo
影响因子：
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作者：
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通讯作者：
Buchsbaum, Monte S.
影响因子：
8.2
作者：
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通讯作者：
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