A system and method to interface with multiple groups of axons in several fascicles of peripheral nerves.
A system and method to interface with multiple groups of axons in several fascicles of peripheral nerves.
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DOI：
10.1016/j.jneumeth.2014.07.020
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发表时间：
2015-04-15
影响因子：
3
通讯作者：
Jung, Ranu
中科院分区：
文献类型：
--
作者：
Thota, Anil K.;Kuntaegowdanahalli, Sathyakumar;Starosciak, Amy K.;Abbas, James J.;Orbay, Jorge;Horch, Kenneth W.;Jung, Ranu
已经开发了几种刺激和/或记录轴突群的神经接口技术。纵向束内电极（LIFE）是一种细导线，可以提供对周围神经束内离散的轴突群的访问。一些应用程序需要能够访问多个分集中的多个离散站点的技术，或者将从这些技术中获益良多。分布式束束内多电极（DIME）引线是为了在多个束束中部署多个life而开发的。它由几个（例如六个）life组成，这些life盘绕并放置在护套中以增强强度和耐用性，其中一部分未盘绕以允许插入不同的位置。我们还开发了一种多导联多电极（MLME）管理系统，其中包括一套护套和制造和部署程序。一个带有3个DIME引线的原型被制造出来，并在尸体手臂上进行了测试。导线成功穿过皮肤和结缔组织，并利用部署程序将life插入两根神经束。大多数多电极系统采用单导联多电极设计。对于某些应用，这种设计可能受到多触点阵列的体积和/或电极的空间分布的限制。我们设计了一个系统，可以用来访问多组离散的纤维，这些纤维在空间上分布在周围神经的一个或多个束中。该系统可用于神经假肢或其他应用。
Several neural interface technologies that stimulate and/or record from groups of axons have been developed. The longitudinal intrafascicular electrode (LIFE) is a fine wire that can provide access to a discrete population of axons within a peripheral nerve fascicle. Some applications require, or would benefit greatly from, technology that could provide access to multiple discrete sites in several fascicles. The distributed intrafascicular multi-electrode (DIME) lead was developed to deploy multiple LIFEs to several fascicles. It consists of several (e.g. six) LIFEs that are coiled and placed in a sheath for strength and durability, with a portion left uncoiled to allow insertion at distinct sites. We have also developed a multi-lead multi-electrode (MLME) management system that includes a set of sheaths and procedures for fabrication and deployment. A prototype with 3 DIME leads was fabricated and tested in a procedure in a cadaver arm. The leads were successfully routed through skin and connective tissue and the deployment procedures were utilized to insert the LIFEs into fascicles of two nerves. Most multi-electrode systems use a single-lead, multi-electrode design. For some applications, this design may be limited by the bulk of the multi-contact array and/or by the spatial distribution of the electrodes. We have designed a system that can be used to access multiple sets of discrete groups of fibers that are spatially distributed in one or more fascicles of peripheral nerves. This system may be useful for neural-enabled prostheses or other applications.
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影响因子：
20.6
作者：
Micera, Silvestro;Citi, Luca;Rossini, Paolo Maria
通讯作者：
Rossini, Paolo Maria
影响因子：
2.5
作者：
Dhillon, GS;Krüger, TB;Horch, KW
通讯作者：
Horch, KW
影响因子：
2.3
作者：
DiMarco, AF
通讯作者：
DiMarco, AF
影响因子：
4.1
作者：
Cameron, T
通讯作者：
Cameron, T
DOI：
10.1682/jrrd.2008.08.0097
发表时间：
2009-01-01
影响因子：
--
作者：
Gustafson, Kenneth J.;Pinault, Gilles C. J.;Triolo, Ronald J.
通讯作者：
Triolo, Ronald J.