Physicochemical properties of mucus and their impact on transmucosal drug delivery.
Physicochemical properties of mucus and their impact on transmucosal drug delivery.
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DOI：
10.1016/j.ijpharm.2017.09.018
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发表时间：
2017-10-30
影响因子：
5.8
通讯作者：
Ghosh D
中科院分区：
文献类型：
--
作者：
Leal J;Smyth HDC;Ghosh D
粘液是颗粒和分子的选择性屏障，防止渗透到粘膜组织的上皮表面。最近在经粘膜给药方面取得了重大进展，并强调了对黏液的基本结构、粘弹性性质和相互作用的理解对设计有效的给药系统具有重要价值。黏液蛋白是黏液的主要非水组分，是一种具有复杂非均相结构的聚合物，其结构域经历各种分子相互作用，如亲疏水、氢键和静电相互作用。这些特性与许多黏液蛋白相关疾病以及通过黏液屏障输送药物直接相关。因此，在这篇综述中，我们讨论了粘液组成、粘液物理化学性质（如孔径、粘弹性、pH值和离子强度）的区域差异。这些因素也讨论了关于粘液性质的变化作为疾病状态的功能。总的来说，该综述旨在为必须应对这一药物输送关键障碍的研究人员提供一个最新的路线图。
Mucus is a selective barrier to particles and molecules, preventing penetration to the epithelial surface of mucosal tissues. Significant advances in transmucosal drug delivery have recently been made and have emphasized that an understanding of the basic structure, viscoelastic properties, and interactions of mucus is of great value in the design of efficient drug delivery systems. Mucins, the primary non-aqueous component of mucus, are polymers carrying a complex and heterogeneous structure with domains that undergo a variety of molecular interactions, such as hydrophilic/hydrophobic, hydrogen bonds and electrostatic interactions. These properties are directly relevant to the numerous mucin-associated diseases, as well as delivering drugs across the mucus barrier. Therefore, in this review we discuss regional differences in mucus composition, mucus physicochemical properties, such as pore size, viscoelasticity, pH, and ionic strength. These factors are also discussed with respect to changes in mucus properties as a function of disease state. Collectively, the review seeks to provide a state of the art roadmap for researchers who must contend with this critical barrier to drug delivery.
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作者：
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