A biomechanical paradigm for axonal insult within the optic nerve head in aging and glaucoma.
A biomechanical paradigm for axonal insult within the optic nerve head in aging and glaucoma.
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DOI：
10.1016/j.exer.2010.09.005
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发表时间：
2011-08
影响因子：
3.4
通讯作者：
Burgoyne, Claude F.
中科院分区：
文献类型：
--
作者：
Burgoyne, Claude F.
关键词：
这篇文章献给罗萨里奥埃尔南德斯，感谢她对我自己工作的热情支持，以及她在整个职业生涯中对同事工作的真诚热情。我第一次见到罗萨里奥是在1991年到1993年，当时我是哈利·奎格利实验室的一名研究员。沿着Harry、John莫里森、Elaine约翰逊、Abe Clark、Colm奥布莱恩和其他许多人，罗萨里奥的工作提供了筛板星形胶质细胞的细胞机制，这些机制在生物力学上是合理的，并且这样做为视神经头（ONH）作为生物力学结构的早期概念提供了可信度。罗萨里奥在年龄和疾病中对ONH星形胶质细胞和筛板细胞的特征描述方面坚持不懈，我们欠她一大笔智力债。有两个问题贯穿于她的工作中，至今仍然至关重要。首先，星形胶质细胞如何响应和改变ONH的生物力学环境和其中产生的生理应力？第二，这些对星形胶质细胞的生理需求如何影响它们对视网膜神经节细胞轴突运输和流动的支持能力？这篇文章的目的是总结什么是已知的生物力学决定因素的视网膜神经节细胞轴突生理学内的ONH的视神经病变的老化和青光眼。我的目标是为这个讨论提供一个生物力学框架。该框架假设ONH星形胶质细胞和神经胶质细胞从根本上支持和影响筛板细胞外基质和视网膜神经节细胞轴突生理学。罗萨里奥埃尔南德斯是最早认识到这种独特情况的影响的调查人员之一。本文所包含的许多想法最初都是在她的作品中提出的，或者是从她的作品中衍生出来的。青光眼的视神经乳头：星形胶质细胞在组织重塑中的作用。Prog Retin Eye Res. 19，297 - 321..青光眼视神经病变的视乳头。眼科学文献115，389 - 395.）。
This article is dedicated to Rosario Hernandez for her warm support of my own work and her genuine enthusiasm for the work of her colleagues throughout her career. I first met Rosario as a research fellow in Harry Quigley’s laboratory between 1991 and 1993. Along with Harry, John Morrison, Elaine Johnson, Abe Clark, Colm O’Brien and many others, Rosario’s work has provided lamina cribrosa astrocyte cellular mechanisms that are biomechanically plausible and in so doing provided credibility to early notions of the optic nerve head (ONH) as a biomechanical structure. We owe a large intellectual debt to Rosario for her dogged persistence in the characterization of the ONH astrocyte and lamina cribrosacyte in age and disease. Two questions run through her work and remain of central importance today. First, how do astrocytes respond to and alter the biomechanical environment of the ONH and the physiologic stresses created therein? Second, how do these physiologic demands on the astrocyte influence their ability to deliver the support to retinal ganglion cell axon transport and flow against the translaminar pressure gradient? The purpose of this article is to summarize what is known about the biomechanical determinants of retinal ganglion cell axon physiology within the ONH in the optic neuropathy of aging and Glaucoma. My goal is to provide a biomechanical framework for this discussion. This framework assumes that the ONH astrocytes and glia fundamentally support and influence both the lamina cribrosa extracellular matrix and retinal ganglion cell axon physiology. Rosario Hernandez was one of the first investigators to recognize the implications of this unique circumstance. Many of the ideas contained herein have been initially presented within or derived from her work (. The optic nerve head in glaucoma: role of astrocytes in tissue remodeling. Prog Retin Eye Res. 19, 297–321.. The optic nerve head in glaucomatous optic neuropathy. Arch Ophthalmol. 115, 389–395.).
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影响因子：
4.4
作者：
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通讯作者：
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影响因子：
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