Plasma selenium levels and nonalcoholic fatty liver disease in Chinese adults: a cross-sectional analysis.
Plasma selenium levels and nonalcoholic fatty liver disease in Chinese adults: a cross-sectional analysis.
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中国成人血浆硒水平与非酒精性脂肪肝：横断面分析。
DOI：
10.1038/srep37288
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发表时间：
2016-11-17
影响因子：
4.6
通讯作者：
Su Q
中科院分区：
文献类型：
--
作者：
Yang Z;Yan C;Liu G;Niu Y;Zhang W;Lu S;Li X;Zhang H;Ning G;Fan J;Qin L;Su Q
硒暴露可诱导动物肝脏胰岛素抵抗和肝脏甘油三酯浓度增加，这可能与非酒精性脂肪性肝病（NAFLD）的风险增加有关。然而，调查血浆硒水平升高与NAFLD之间关系的流行病学研究尚不可用。我们的目的是调查硒水平与中国成人NAFLD患病率的关系。这是一项在中国上海进行的8550名40岁或以上中国成年人的横断面研究。问卷调查，人体测量和实验室检查进行。在排除酒精滥用和其他肝脏疾病后，通过肝脏超声诊断NAFLD。通过电感耦合等离子体质谱法评估血浆硒浓度。血浆硒浓度中位数为213.0 μg/L。血浆硒水平升高与甘油三酯、低密度脂蛋白胆固醇、空腹血糖、负荷后血糖、A1 c、HOMA-IR以及ALT、AST和γ-GT升高相关（均P < 0.05）。在调整潜在的共同创始者后，与最低四分位数相比，最高四分位数的NAFLD的比值比（OR = 1.54，95%CI 1.13-2.18）显著更高。这项研究的结果提供了流行病学证据，血浆硒水平升高与NAFLD患病率升高有关。
Selenium exposure can induce liver insulin resistance and increased liver triglyceride concentrations in animals, which may link to an increased risk of nonalcoholic fatty liver disease (NAFLD). However, epidemiological studies investigating the association between elevated plasma selenium levels and NAFLD were not available. We aimed to investigate the association of selenium levels with the prevalence of NAFLD in Chinese adults. This was a cross-sectional study of 8550 Chinese adults aged 40 yr or older in Shanghai, China. A questionnaire, anthropometric measurements, and laboratory tests were conducted. NAFLD was diagnosed by hepatic ultrasound after the exclusion of alcohol abuse and other liver diseases. Plasma selenium concentration was assessed by inductively coupled plasma mass spectroscopy. The median concentration of plasma selenium was 213.0 μg/L. Elevated plasma selenium levels were associated with higher triglycerides, LDL-cholesterol, fasting plasma glucose, post-loading plasma glucose, A1c, HOMA-IR, as well as ALT, AST and γ-GT (all P < 0.05). The odds ratios were substantially higher for NAFLD (OR = 1.54, 95% CI 1.13–2.18) in the highest selenium quartile compared with those in the lowest quartile, after adjustment for potential cofounder. The results of this study provided epidemiological evidence that increased plasma selenium level is associated with elevated prevalence of NAFLD.
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影响因子：
7.1
作者：
LONGNECKER, MP;TAYLOR, PR;WILLETT, WC
通讯作者：
WILLETT, WC
影响因子：
25.7
作者：
Li, Youming;Xu, Chengfu;Miao, Min
通讯作者：
Miao, Min
DOI：
10.1111/j.1440-1746.2007.05002.x
发表时间：
2007-06-01
影响因子：
4.1
作者：
Farrell, Geoffrey C.;Chitturi, Shivakumar;Sollano, Jose D.
通讯作者：
Sollano, Jose D.
影响因子：
4.2
作者：
BURK, RF;BROWN, DG;SEELY, RJ
通讯作者：
SEELY, RJ
影响因子：
6.3
作者：
LLOYD, B;LLOYD, RS;CLAYTON, BE
通讯作者：
CLAYTON, BE