Input- and cell-type-specific endocannabinoid-dependent LTD in the striatum.
Input- and cell-type-specific endocannabinoid-dependent LTD in the striatum.
复制标题
DOI：
10.1016/j.celrep.2014.12.005
复制
发表时间：
2015-01-06
期刊：
影响因子：
8.8
通讯作者：
Ding JB
中科院分区：
文献类型：
--
作者：
Wu YW;Kim JI;Tawfik VL;Lalchandani RR;Scherrer G;Ding JB
运动学习需要皮质纹状体和丘脑纹状体水平的基底节区可塑性的改变。内源性大麻素依赖性长期抑制（eCB-LTD）是在这些谷氨酸能输入中表达的突触可塑性的主要形式；然而，是否可以在所有纹状体神经元的所有输入中诱导eCB-LTD仍有争议。利用区域特异性Cre小鼠系结合光遗传学技术，我们直接研究并区分了皮质纹状体和丘脑纹状体的投影。我们发现eCB-LTD在皮质纹状体突触成功诱导，独立于突触后纹状体棘突神经元（SPN）亚型。相反，eCB-LTD仅在名义上存在于丘脑纹状体突触。这种二分法可归因于大麻素1型（CB1）受体在丘脑纹状体末端的最小表达。此外，在LTD诱导过程中，SPN上多巴胺受体的共同激活重新建立了SPN亚型依赖性的eb -LTD。总之，我们的发现为理解皮质纹状体和丘脑纹状体突触可塑性以及纹状体eCB-LTD在运动学习中的作用奠定了基础。
Changes in basal ganglia plasticity at the corticostriatal and thalamostriatal level are required for motor learning. Endocannabinoid-dependent long-term depression (eCB-LTD) is known to be a dominant form of synaptic plasticity expressed at these glutamatergic inputs; however, whether eCB-LTD can be induced at all inputs on all striatal neurons is still debatable. Using region-specific Cre mouse lines combined with optogenetic techniques, we directly investigated and distinguished between corticostriatal and thalamostriatal projections. We found that eCB-LTD was successfully induced at corticostriatal synapses, independent of postsynaptic striatal spiny projection neuron (SPN) subtype. Conversely, eCB-LTD was only nominally present at thalamostriatal synapses. This dichotomy was attributable to the minimal expression of cannabinoid type-1 (CB1) receptors on thalamostriatal terminals. Furthermore, co-activation of dopamine receptors on SPNs during LTD induction re-established SPN subtype-dependent eCB-LTD. Altogether, our findings lay the groundwork for understanding corticostriatal and thalamostriatal synaptic plasticity and for striatal eCB-LTD in motor learning.
登录
查看更多内容
影响因子：
16.2
作者：
Kreitzer, AC;Carter, AG;Regehr, WG
通讯作者：
Regehr, WG
影响因子：
25
作者：
Glickfeld, Lindsey L.;Andermann, Mark L.;Bonin, Vincent;Reid, R. Clay
通讯作者：
Reid, R. Clay
影响因子：
25
作者：
Giuffrida, A;Parsons, LH;Piomelli, D
通讯作者：
Piomelli, D
影响因子：
16.2
作者：
Arenkiel, Benjamin R.;Peca, Joao;Feng, Guoping
通讯作者：
Feng, Guoping
影响因子：
25
作者：
Gerdeman, GL;Ronesi, J;Lovinger, DM
通讯作者：
Lovinger, DM