Mechanisms and physiological impact of the dual localization of mitochondrial intermembrane space proteins.

Mechanisms and physiological impact of the dual localization of mitochondrial intermembrane space proteins.
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线粒体膜间隙蛋白双重定位的机制和生理影响

DOI:
10.1042/bst20140104
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发表时间:
2014
影响因子:
3.9
通讯作者:
Riemer J
Riemer J
中科院分区:
生物学3区
文献类型:
--
作者:
Petrungaro C;Riemer J

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真核细胞发展了多种机制来引导蛋白质到达细胞内的多个目的地。最近,酵母细胞线粒体膜间隙(IMS)的蛋白质组被确定,表明大约20%的可溶性IMS蛋白双定位于IMS以及其他细胞区室。这些双重定位的蛋白质中有一半对氧化应激防御很重要,另一半参与能量平衡。在本综述中,我们讨论了导致IMS蛋白双定位的机制及其对线粒体功能的影响。
Eukaryotic cells developed diverse mechanisms to guide proteins to more than one destination within the cell. Recently, the proteome of the IMS (intermembrane space) of mitochondria of yeast cells was identified showing that approximately 20% of all soluble IMS proteins are dually localized to the IMS, as well as to other cellular compartments. Half of these dually localized proteins are important for oxidative stress defence and the other half are involved in energy homoeostasis. In the present review, we discuss the mechanisms leading to the dual localization of IMS proteins and the implications for mitochondrial function.
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