Neurotrophins Time Point Intervention after Traumatic Brain Injury: From Zebrafish to Human.
Neurotrophins Time Point Intervention after Traumatic Brain Injury: From Zebrafish to Human.
复制标题
脑损伤后神经营养蛋白的时间点干预：从斑马鱼到人。
DOI：
10.3390/ijms22041585
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发表时间：
2021-02-04
影响因子：
5.6
通讯作者：
Cacialli P
中科院分区：
文献类型：
--
作者：
Cacialli P
创伤性脑损伤（TBI）仍然是导致长期残疾的主要原因，每年涉及数百万人。几项关于哺乳动物的研究报告称，神经营养物质在中风和脑外伤等神经退行性疾病后的保护和功能恢复中发挥了重要作用。在斑马鱼模型中也报道了脑外伤后神经营养物质的保护作用。然而，哺乳动物大脑的修复机制是有限的，新形成的神经元不能存活很长时间。相比之下，成年鱼脑损伤后具有较高的再生特性。哺乳动物和鱼类脑再生特性的显著差异归因于成体神经发生过程的显著差异。然而，目前尚不清楚每种神经营养因子和受体在脑损伤后的具体作用和时间点贡献在脊椎动物进化过程中是否保守。因此，在这篇综述中，我报道了斑马鱼和哺乳动物TBI事件后每种神经营养因子和受体的干预的具体作用和时间点。
Traumatic brain injury (TBI) remains the leading cause of long-term disability, which annually involves millions of individuals. Several studies on mammals reported that neurotrophins could play a significant role in both protection and recovery of function following neurodegenerative diseases such as stroke and TBI. This protective role of neurotrophins after an event of TBI has also been reported in the zebrafish model. Nevertheless, reparative mechanisms in mammalian brain are limited, and newly formed neurons do not survive for a long time. In contrast, the brain of adult fish has high regenerative properties after brain injury. The evident differences in regenerative properties between mammalian and fish brain have been ascribed to remarkable different adult neurogenesis processes. However, it is not clear if the specific role and time point contribution of each neurotrophin and receptor after TBI is conserved during vertebrate evolution. Therefore, in this review, I reported the specific role and time point of intervention for each neurotrophic factor and receptor after an event of TBI in zebrafish and mammals.
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影响因子：
3.7
作者：
Cacialli P;Gueguen MM;Coumailleau P;D'Angelo L;Kah O;Lucini C;Pellegrini E
通讯作者：
Pellegrini E
影响因子：
3.5
作者：
Beatriz Cragnolini, Andrea;Montenegro, Gonzalo;Hugo Masco, Daniel
通讯作者：
Hugo Masco, Daniel
影响因子：
16.2
作者：
Atwal, JK;Massie, B;Kaplan, DR
通讯作者：
Kaplan, DR
影响因子：
4.6
作者：
Chapouton, Prisca;Adolf, Birgit;Bally-Cuif, Laure
通讯作者：
Bally-Cuif, Laure
影响因子：
2.5
作者：
Cacialli, Pietro;D'angelo, Livia;Lucini, Carla
通讯作者：
Lucini, Carla