Gray areas: Neuropeptide circuits linking the Edinger-Westphal and Dorsal Raphe nuclei in addiction.
Gray areas: Neuropeptide circuits linking the Edinger-Westphal and Dorsal Raphe nuclei in addiction.
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DOI：
10.1016/j.neuropharm.2021.108769
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发表时间：
2021-10-15
影响因子：
4.7
通讯作者：
Giardino WJ
中科院分区：
文献类型：
--
作者：
Pomrenze MB;Walker LC;Giardino WJ
成瘾的回路包括几个神经网络，包括中脑-一个广泛的区域，主要参与控制动机行为。中脑核团如Edinger-Westphal（EW）和中缝背核（DR）含有独特的神经元群，这些神经元群合成许多尚未研究的神经活性分子，并被导水管周围灰质（PAG）包围。尽管这些特殊的神经元类的腹侧中脑复合体和周围的PAG的接近，EW和DR的功能仍然大大低于调查比较。这些不同的细胞群在小鼠前睑后方约-3.0至-5.2毫米处形成一个连续的神经元，我们统称为导水管下旁正中带。定义这些通路如何调节情感行为状态，对于当今神经科学的技术进步来说是一个困难但可以克服的挑战。在这篇综述中，我们涵盖了已知的贡献不同的神经亚型的下导水管旁正中带。我们根据它们的空间、分子、连接性和功能特性对这些细胞类型进行分类，并将这些信息与成瘾中EW和DR的现有数据相结合。接下来，我们将讨论在解剖学和功能上将EW和DR联系起来的证据，突出EW-DR回路对成瘾相关行为的潜在贡献。总的来说，我们的目标是得到一个综合框架，强调EW和DR核成瘾状态的贡献，并描述了这些细胞群如何在患有物质使用障碍的个体中发挥作用。
The circuitry of addiction comprises several neural networks including the midbrain- an expansive region critically involved in the control of motivated behaviors. Midbrain nuclei like the Edinger-Westphal (EW) and dorsal raphe (DR) contain unique populations of neurons that synthesize many understudied neuroactive molecules and are encircled by the periaqueductal gray (PAG). Despite the proximity of these special neuron classes to the ventral midbrain complex and surrounding PAG, functions of the EW and DR remain substantially underinvestigated by comparison. Spanning approximately −3.0 to −5.2mm posterior from bregma in the mouse, these various cell groups form a continuum of neurons that we refer to collectively as the subaqueductal paramedian zone. Defining how these pathways modulate affective behavioral states presents a difficult, yet conquerable challenge for today’s technological advances in neuroscience. In this review, we cover the known contributions of different neuronal subtypes of the subaqueductal paramedian zone. We catalogue these cell types based on their spatial, molecular, connectivity, and functional properties and integrate this information with the existing data on the EW and DR in addiction. We next discuss evidence that links the EW and DR anatomically and functionally, highlighting the potential contributions of an EW-DR circuit to addiction-related behaviors. Overall, we aim to derive an integrated framework that emphasizes the contributions of EW and DR nuclei to addictive states and describes how these cell groups function in individuals suffering from substance use disorders.
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