Posttraumatic stress disorder (PTSD), sleep, and cardiovascular disease risk: A mechanism-focused narrative review.
Posttraumatic stress disorder (PTSD), sleep, and cardiovascular disease risk: A mechanism-focused narrative review.
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DOI：
10.1037/hea0001143
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发表时间：
2022-10
影响因子：
4.2
通讯作者：
Sumner, Jennifer A.
中科院分区：
文献类型：
--
作者：
Meinhausen, Corinne;Prather, Aric A.;Sumner, Jennifer A.
越来越多的纵向研究表明，创伤后应激障碍（PTSD）先于并预测心血管疾病（CVD）的发作，以及许多生理（例如，下丘脑-垂体-肾上腺轴和自主神经系统的失调，慢性全身性炎症）和行为（例如，缺乏运动、吸烟、不良饮食）因素可能是这种关联的基础。在这篇叙述性综述中，我们将重点放在睡眠作为一个可改变的风险因素，将PTSD与CVD联系起来。我们总结了创伤暴露后睡眠障碍的证据和睡眠不良的潜在心脏毒性作用，重点是机制。此外，我们还回顾了在PTSD-CVD风险关系的背景下研究睡眠的文献。虽然睡眠障碍是PTSD的标志性症状，也是CVD发展的公认危险因素，但在现有文献中，睡眠在PTSD和CVD之间的关联中的作用在很大程度上尚未得到研究。然而，这些工作有可能提高我们对风险机制的理解，并为干预措施提供信息，以抵消创伤后心血管疾病风险的升高。我们概述了未来研究和行为医学模型的几项建议，以帮助定义和解决创伤暴露的PTSD个体中睡眠行为在CVD发展中的作用。
Growing longitudinal research has demonstrated that posttraumatic stress disorder (PTSD) precedes and predicts the onset of cardiovascular disease (CVD), and a number of physiological (e.g., dysregulation of the hypothalamic-pituitary-adrenal axis and autonomic nervous system, chronic systemic inflammation) and behavioral (e.g., physical inactivity, smoking, poor diet) factors may underlie this association. In this narrative review, we focus on sleep as a modifiable risk factor linking PTSD with CVD. We summarize the evidence for sleep disturbance after trauma exposure and the potential cardiotoxic effects of poor sleep, with an emphasis on mechanisms. In addition, we review the literature that has examined sleep in the context of the PTSD-CVD risk relation. Although sleep disturbance is a hallmark symptom of PTSD and a well-established risk factor for the development of CVD, the role of sleep in the association between PTSD and CVD has been largely unexamined in the extant literature. However, such work has the potential to improve our understanding of mechanisms of risk and inform intervention efforts to offset elevated CVD risk after trauma. We outline several recommendations for future research and behavioral medicine models in order to help define and address the role of sleep behavior in the development of CVD among trauma-exposed individuals with PTSD.
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影响因子：
3.3
作者：
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通讯作者：
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通讯作者：
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