The Maize MID-COMPLEMENTING ACTIVITY Homolog CELL NUMBER REGULATOR13/NARROW ODD DWARF Coordinates Organ Growth and Tissue Patterning[OPEN]
The Maize MID-COMPLEMENTING ACTIVITY Homolog CELL NUMBER REGULATOR13/NARROW ODD DWARF Coordinates Organ Growth and Tissue Patterning[OPEN]
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玉米中补体活性同源细胞数调节器13/窄奇矮矮化协调器官生长和组织模式[打开]
DOI：
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
S. Hake
中科院分区：
文献类型：
--
作者：
Marisa Rosa;M. Abraham;M. Lewis;J. P. Fonseca;Wang Tian;Vicente Ramírez;S. Luan;M. Pauly;S. Hake
表型和转录组分析表明，窄奇矮，中间互补活性同源物，调节器官生长，组织模式，和病原体的反应在玉米。器官发生通过细胞分裂、扩张和分化发生。这些细胞过程是如何协调的仍然是难以捉摸的。玉米（Zea mays）叶提供了一个强大的系统，研究细胞分化，由于其独特的组织和细胞类型。窄奇矮（nod）突变体在细胞和组织水平上都表现出缺陷，在整个生长过程中严重程度增加。与野生型相比，NOD突变体叶由于细胞更少和更小而具有减小的尺寸。青少年到成人的过渡被推迟，近端远端图案是异常的，在这个突变体。特化细胞如形成气孔和毛状体的细胞的分化是不完全的。对nod-1扇区的分析表明，NOD在叶片中发挥细胞自主功能。我们对nod进行了定位克隆，发现它编码玉米中间互补活性同源物细胞数调节因子13（CNR 13）。CNR 13/NOD定位于细胞膜，并在分裂组织中富集。nod突变体的转录组分析揭示了细胞壁，激素代谢和防御基因类别的过度表达。我们建议，NOD协调细胞活动响应内在和外在的线索。
Phenotypic and transcriptome analysis indicate that NARROW ODD DWARF, the MID-COMPLEMENTING ACTIVITY homolog, regulates organ growth, tissue patterning, and pathogen responses in maize. Organogenesis occurs through cell division, expansion, and differentiation. How these cellular processes are coordinated remains elusive. The maize (Zea mays) leaf provides a robust system to study cellular differentiation due to its distinct tissues and cell types. The narrow odd dwarf (nod) mutant displays defects at both the cellular and tissue level that increase in severity throughout growth. nod mutant leaves have reduced size due to fewer and smaller cells compared with the wild type. The juvenile-to-adult transition is delayed, and proximal distal-patterning is abnormal in this mutant. Differentiation of specialized cells such as those forming stomata and trichomes is incomplete. Analysis of nod-1 sectors suggests that NOD plays a cell-autonomous function in the leaf. We cloned nod positionally and found that it encodes CELL NUMBER REGULATOR13 (CNR13), the maize MID-COMPLEMENTING ACTIVITY homolog. CNR13/NOD is localized to the membrane and is enriched in dividing tissues. Transcriptome analysis of nod mutants revealed overrepresentation of cell wall, hormone metabolism, and defense gene categories. We propose that NOD coordinates cell activity in response to intrinsic and extrinsic cues.
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DOI：
10.1083/jcb.152.1.231
发表时间：
2001-01-08
期刊：
The Journal of cell biology
影响因子：
--
作者：
Smith LG;Gerttula SM;Han S;Levy J
通讯作者：
Levy J
影响因子：
3.3
作者：
Eric M. Muller;Emily G. Locke;Kyle W. Cunningham
通讯作者：
Eric M. Muller;Emily G. Locke;Kyle W. Cunningham
影响因子：
7.2
作者：
Earley, KW;Haag, JR;Pikaard, CS
通讯作者：
Pikaard, CS
影响因子：
10.5
作者：
Moreno, MA;Harper, LC;Freeling, M
通讯作者：
Freeling, M
影响因子：
4.8
作者：
Khan, Mamoona;Rozhon, Wilfried;Poppenberger, Brigitte
通讯作者：
Poppenberger, Brigitte