Visual acuity changes in cone and cone‐rod dystrophies
Visual acuity changes in cone and cone‐rod dystrophies
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视锥细胞和视锥杆营养不良的视力变化
DOI：
10.1111/j.1475-1313.2011.00883.x
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发表时间：
2012
影响因子：
2.9
通讯作者：
Zrenner E
中科院分区：
文献类型：
--
作者：
Prokofyeva E;Troeger E;Bernd A;Zrenner E
引文信息：Prokofyeva E，Troeger E，Bernd A & Zrenner E.视锥细胞和视锥-视杆细胞营养不良的视力变化。眼科生理学Opt 2011。土井：10.1111/j.1475 - 1313.2011.00883.x摘要目的：本研究的目的是评估视锥细胞（CD）和视锥-视杆细胞营养不良（CRD）的纵向视力（VA）变化，以制定随访策略的建议，并确定潜在治疗干预的最佳时间。方法：临床定义的CD和CRD患者，在至少2年的随访期内至少进行了3次临床检查 ，被纳入本研究。观察期分为两个阶段：1-2次访视和2-3次访视，间隔2年; 3-4次访视，间隔3年。 在基线检查期间收集病史。估计了中位发病年龄、首次检查时的年龄以及疾病发病与首次访视之间的时间（潜伏期）。计算每个观察段的logMAR VA降低的第25和第75分位数的中位数。VA下降的中位数百分比也calculated.Results：初步结果的图宾根纵向研究的VA变化在CRD和CD的中位数与第25和第75五分位数。研究了29例患者（14例男性和15例女性）。其中19例为CRD，10例为CD。基线访视时CRD的中位年龄为18（11，31）岁，CD为26（8，41.5）岁。CRD的中位发病年龄为9（8，25）岁，CD为7.5（5，15）岁。CD患者的中位潜伏期为6.5（3; 8.25）年，CRD患者为4（2，10）年。CD和CRD患者的VA仅在首次访视时有显著差异（p<0.03）。 CDR的VA降低在2-3次访视之间最高，中位VA降低36%，CD的VA降低在3-4次访视之间最高，中位VA降低80%。在CRD组的VA下降率是相当均匀的四个访问，而在CD组的下降似乎逐步增加到年底的follow-up.Conclusion：CRD患者比那些与CD在基线访视，并有一个较长的随访期。仅在首次眼科检查时观察到CRD和CD的VA存在统计学显著差异。VA降低在CRD患者生命的第二个十年和CD患者的第三个十年最为显著。CRD的特征是比CD更渐进的VA降低。CRD在第二次和第三次检查时VA下降幅度较大，而CD的VA下降在随访期结束时（第四次检查）进展。在建议和长期随访此类患者时，应考虑这些结果。
Citation information:Prokofyeva E, Troeger E, Bernd A & Zrenner E. Visual acuity changes in cone and cone‐rod dystrophies.Ophthalmic Physiol Opt2011. doi: 10.1111/j.1475‐1313.2011.00883.xAbstractPurpose:The purpose of the study was to evaluate longitudinal visual acuity (VA) changes in cone (CD) and cone‐rod dystrophies (CRD) in order to develop recommendations for follow‐up strategies and to define an optimal time for potential therapeutic intervention.Methods:Patients with clinically defined CD and CRD, who had at least three clinical examinations within a follow‐up period of a minimum of 2 years, were included in the study. The observation period was divided into segments: between 1–2 visits and 2–3 visits in intervals of 2 years, and between 3–4 visits in 3‐year intervals. Disease history was collected during the baseline examination. Median age of onset, age at first examination, and period between disease onset and 1st visit (latency) were estimated. Medians with 25th and 75th quantile of VA decrease in logMAR for each segment of observation were calculated. The median percentage of VA decrease was also calculated.Results:Initial results of the Tuebingen longitudinal study of VA changes in CRD and CD are presented as medians with 25th and 75th quintiles. Twenty‐nine patients (14 men and 15 women) were studied. Nineteen of them had CRD and 10 CD. Median age at the baseline visit was 18 (11, 31) years for CRD and 26 (8, 41.5) years for CD. Median age of disease onset was 9 (8, 25) years for CRD and 7.5 (5, 15) years for CD. The median latency was 6.5 (3; 8.25) years in CD and 4 (2, 10) years in CRD patients. VA in CD and CRD patients was significantly different only during the first visit (p< 0.03). VA decrease was highest in the period between 2–3 visits with a median VA decrease of 36%, for CDR and between 3–4 visits for CD with a median VA decrease of 80%. In the CRD group the rate of VA decline was fairly even over the four visits, whereas in the CD group the decline appeared to progressively increase towards the end of the follow‐up.Conclusion:CRD patients were younger than those with CD at a baseline visit and had a longer period of follow‐up. A statistically significant difference in VA in CRD and CD was observed at the first ophthalmological examination only. VA decrease was most prominent in the second decade of life in CRD and in third decade in CD patients. CRD was characterized by a more progressive VA decrease than CD. CRD had a high decline of VA over the second and the third examination, whereas VA decline in CD progressed towards the end of follow‐up period (fourth examination). These results should be considered when advising and following up such patients on a long‐term basis.
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