Threading the Pieces Together: Integrative Perspective on SARS-CoV-2.
Threading the Pieces Together: Integrative Perspective on SARS-CoV-2.
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将碎片串在一起：对SARS-CoV-2的综合观点。
DOI：
10.3390/pathogens9110912
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发表时间：
2020-11-04
期刊：
影响因子：
--
通讯作者：
Pandey R
中科院分区：
文献类型：
--
作者：
Kanakan A;Mishra N;Srinivasa Vasudevan J;Sahni S;Khan A;Sharma S;Pandey R
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）大流行对全球研究界提出了挑战，要求他们进行创新、互动和跨层次整合研究结果。对SARS-CoV-2的研究产生了大量跨越多个平行点的数据，包括临床数据、SARS-CoV-2基因组结构、通过转录组和遗传变异捕获的宿主反应、微生物共感染（宏基因组）和共病。在COVID-19的情况下，疾病表型呈现出令人感兴趣的复杂性，其中包括广泛的有症状至无症状个体，进一步加剧了有症状个体所表现出的临床症状谱内的巨大异质性。临床结果进一步受到感染时共病状况的影响。COVID-19大流行产生了大量的文献，涉及SARS-CoV-2的许多方面，从因果关系到结果，从易感性到保护性（可能），从合并感染到合并症，以及全球范围内的死亡率差异。挑战带来机遇，而当前这一大流行病的挑战则突出表明，有必要和有机会努力采取一种综合办法，将多种变量联系起来。通过这次审查，我们努力汇集跨越不同领域的信息，以促进全球研究人员对SARS-CoV-2的反应。
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has challenged the research community globally to innovate, interact, and integrate findings across hierarchies. Research on SARS-CoV-2 has produced an abundance of data spanning multiple parallels, including clinical data, SARS-CoV-2 genome architecture, host response captured through transcriptome and genetic variants, microbial co-infections (metagenome), and comorbidities. Disease phenotypes in the case of COVID-19 present an intriguing complexity that includes a broad range of symptomatic to asymptomatic individuals, further compounded by a vast heterogeneity within the spectrum of clinical symptoms displayed by the symptomatic individuals. The clinical outcome is further modulated by the presence of comorbid conditions at the point of infection. The COVID-19 pandemic has produced an expansive wealth of literature touching many aspects of SARS-CoV-2 ranging from causal to outcome, predisposition to protective (possible), co-infection to comorbidity, and differential mortality globally. As challenges provide opportunities, the current pandemic’s challenge has underscored the need and opportunity to work for an integrative approach that may be able to thread together the multiple variables. Through this review, we have made an effort towards bringing together information spanning across different domains to facilitate researchers globally in pursuit of their response to SARS-CoV-2.
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影响因子：
5.2
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通讯作者：
Rice, Gillian I.
影响因子：
6.4
作者：
Chan, Kelvin Y. K.;Ching, Johannes C. Y.;Khoo, Ui-Soon
通讯作者：
Khoo, Ui-Soon