Heat increases MDMA-enhanced NAcc 5-HT and body temperature, but not MDMA self-administration.
Heat increases MDMA-enhanced NAcc 5-HT and body temperature, but not MDMA self-administration.
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DOI：
10.1016/j.euroneuro.2010.08.009
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发表时间：
2010-12
影响因子：
5.6
通讯作者：
Duvauchelle, Christine L.
中科院分区：
文献类型：
--
作者：
Feduccia, Allison A.;Kongovi, Nundhun;Duvauchelle, Christine L.
令人关切的是，炎热的环境会增强3，4-亚甲二氧基甲基苯丙胺（MDMA或“摇头丸”）的不良影响。在本研究中，在正常和高温条件（23° C或32° C）下对大鼠进行了长期（4周）每日MDMA自我给药和MDMA激发试验。在MDMA自我给药期间，活动和体温因热或MDMA经验而增加，而MDMA自我给药率随经验增加而增加，但在热条件下具有可比性。在MDMA激发试验（3.0 mg/kg，i. v.）中，在体微透析显示，在两种热条件下，丘脑核5-羟色胺（NAcc 5-HT）和多巴胺（DA）反应均显著增加。在加热的环境中，MDMA刺激的5-HT反应和核心温度（但不是DA）显着大于室温。虽然加热的环境并没有急剧增加MDMA的摄入量，但NAcc对MDMA的5-HT反应过度可能导致5-HT耗竭;这是一种与兴奋性使用升级和神经功能障碍改变情绪和认知有关的疾病。
There is concern that hot environments enhance adverse effects of 3,4-methylenedioxymethamphetamine (MDMA or “Ecstasy”). In this study, long-term (4-wks) daily MDMA self-administration sessions and an MDMA challenge test were conducted with rats under normal and high thermal conditions (23° or 32° C). During MDMA self-administration sessions, activity and body temperature were increased by heat or MDMA experience, while MDMA self-administration rates increased with experience, but were comparable between thermal conditions. At the MDMA challenge test (3.0 mg/kg, i.v.), in vivo microdialysis showed nucleus accumbens serotonin (NAcc 5-HT) and dopamine (DA) responses were significantly increased in both thermal conditions. In the heated environment, MDMA-stimulated 5-HT responses and core temperature (but not DA) were significantly greater than at room temperature. Though the heated environment did not acutely boost MDMA intake, exaggerated NAcc 5-HT responses to MDMA may result in 5-HT depletion; a condition associated with Ecstasy use escalation and neural dysfunctions altering mood and cognition.
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影响因子：
4.2
作者：
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通讯作者：
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影响因子：
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