High-resolution functional magnetic resonance imaging mapping of noxious heat and tactile activations along the central sulcus in New World monkeys.
High-resolution functional magnetic resonance imaging mapping of noxious heat and tactile activations along the central sulcus in New World monkeys.
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DOI：
10.1016/j.pain.2010.10.048
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发表时间：
2011-03
期刊：
影响因子：
7.4
通讯作者：
Avison MJ
中科院分区：
文献类型：
--
作者：
Chen LM;Dillenburger BC;Wang F;Friedman RM;Avison MJ
本研究使用9.4T的高分辨率BOLD功能磁共振成像技术，在麻醉松鼠中央沟周围的皮质区域定位了触觉和伤害性热刺激的精细尺度功能表征。伤害性热刺激(47.5°C)可引起多次空间上不同的局灶性BOLD激活。在3a、3b、1和2区观察到一致的激活，而在M1区激活频率较低。与触觉刺激相比，热伤害性刺激覆盖了更多的区域，在每个功能区内形成了多个焦点。总体而言，3b区的伤害性热激活不会与触觉反应共存。不同动物3a区和1/2区的热激活和触觉激活的空间关系是不同的。随后的电生理标测证实，诱发的热和触觉BOLD信号在体感上是合适的。对于有害的热刺激，大胆信号的大小和时间分布在不同的皮质区域是不同的。峰值相对较晚，但在3b和2区观察到较强的信号；而峰值较早，但在3a、1和m1区观察到较弱的信号。综上所述，本研究不仅证实了3a、3b和1区的躯体感觉区的参与，而且确认了2区和M1区参与了热伤害性信息的加工。中央沟不同皮质区域的不同BOLD反应曲线表明，这些区域在伤害性输入的编码中扮演不同的角色。热伤害性和触觉输入可能由不同区域的不同神经元簇处理。
This study mapped the fine scale functional representation of tactile and noxious heat stimuli in cortical areas around the central sulcus of anesthetized squirrel monkeys by using high-resolution BOLD fMRI at 9.4T. Noxious heat (47.5 °C) stimulation of digits evoked multiple spatially distinct and focal BOLD activations. Consistent activations were observed in areas 3a, 3b, 1 and 2 while less frequent activation was present in M1. Compared to tactile activations, thermal nociceptive activations covered more area and formed multiple foci within each functional area. In general, noxious heat activations in area 3b did not colocalize with tactile responses. The spatial relationships of heat and tactile activations in areas 3a and 1/2 varied across animals. Subsequent electrophysiological mapping confirmed the evoked heat and tactile BOLD signals were somatotopically appropriate. The magnitude and temporal profiles of the BOLD signals to noxious heat stimuli differed across cortical areas. Comparatively late peaking, but stronger signals were observed in areas 3b and 2; whereas earlier peaking, but weaker signals were observed in areas 3a, 1 and M1. In sum, this study not only confirmed the involvement of somatosensory areas of 3a, 3b, and 1, but also identified the engagements of area 2 and M1 in the processing of heat nociceptive inputs. Differential BOLD response profiles of the individual cortical areas along the central sulcus suggest these areas play different roles in the encoding of nociceptive inputs. Thermal nociceptive and tactile inputs may be processed by different clusters of neurons in different areas.
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影响因子：
7.4
作者：
Chen LM;Friedman RM;Roe AW
通讯作者：
Roe AW
影响因子：
2.5
作者：
Friedman, Robert M.;Chen, Li Min;Roe, Anna W.
通讯作者：
Roe, Anna W.
DOI：
10.1098/rstb.2000.0563
发表时间：
2000-02-29
影响因子：
6.3
作者：
Iwamura, Y
通讯作者：
Iwamura, Y
影响因子：
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作者：
Lefaucheur, J. P.;Drouot, X.;Nguyen, J. P.
通讯作者：
Nguyen, J. P.
影响因子：
3
作者：
Chen, LM;Heider, B;Roe, AW
通讯作者：
Roe, AW