Investigating the relationship between precocious puberty and obesity: a cross-sectional study in Shanghai, China.
Investigating the relationship between precocious puberty and obesity: a cross-sectional study in Shanghai, China.
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调查性早熟与肥胖之间的关系：中国上海的一项横断面研究
DOI：
10.1136/bmjopen-2016-014004
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发表时间：
2017-04-11
期刊：
影响因子：
2.9
通讯作者：
Jiang F
中科院分区：
文献类型：
--
作者：
Chen C;Zhang Y;Sun W;Chen Y;Jiang Y;Song Y;Lin Q;Zhu L;Zhu Q;Wang X;Liu S;Jiang F
目的肥胖与性发育早期密切相关，但性早熟与肥胖或向心性肥胖的关系目前仍不一致，尤其是在男孩中。本研究旨在探讨性早熟与肥胖及中心性肥胖的关系。设计：采用多阶段分层整群随机抽样的大规模人群横断面研究。数据来源于2014年6月的上海儿童健康、教育和生活方式评估（SCHE）研究。研究对象为17620名6-12岁的中国儿童。主要和次要结局指标肥胖由WHO儿童生长标准定义。中心性肥胖定义为性别特异性腰围身高比（WHtR）临界值（男孩WHtR ≥0.48，女孩WHtR ≥0.46）。根据乳房、阴毛和睾丸发育的坦纳分期确定性早熟。进行χ2检验以比较比率。计算比值比（OR）和95%置信区间（CI），以评估性早熟与全身性肥胖和中心性肥胖之间的关系。概率分析用于估计乳房、阴毛和睾丸发育进入坦纳2期或以上的中位年龄。采用线性回归分析比较WHtR和体重指数（BMI）对性发育指标的影响。结果25.98%和38.58%的性早熟患儿伴发肥胖（OR=2.15，95%CI =1.31 ~ 3.50）或向心性肥胖（OR=2.10，95% CI=1.46 ~ 3.03）;性早熟女童中分别有13.86%和29.42%伴有肥胖（OR=9.00，95% CI=5.60 ~ 14.46）或向心性肥胖（OR=5.40，95% CI=4.10 ~ 7.12）。中心性肥胖儿童乳房、阴毛和睾丸发育的中位年龄随BMI的增加而降低，乳房和睾丸发育的中位年龄较阴毛早。结论青春发育早与儿童肥胖和中心性肥胖呈正相关。
Objectives Obesity is reported to be closely relevant to early sexual development but the relationship between sexual precocity and obesity or central obesity is still inconsistent, especially in boys. We aimed to investigate the relationship between precocious puberty and obesity as well as central obesity. Design A large population-based cross-sectional study using multistage, stratified cluster random sampling. Setting Data from the Shanghai Children’s Health, Education and Lifestyle Evaluation (SCHEDULE) study in June 2014. Participants 17 620 Chinese children aged 6–12 years. Primary and secondary outcome measures Obesity was defined by WHO Child Growth Standards. Central obesity was defined by sex-specific waist-to-height ratio (WHtR) cut-offs (WHtR ≥0.48 for boys, WHtR ≥0.46 for girls). Precocious puberty was identified by Tanner stage of breast, pubic hair and testicle development. A χ2 test was performed to compare rates. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the association between precocious puberty and general obesity and central obesity. Probit analysis was used for estimating the median age at entry into Tanner stage 2 or greater for breast, pubic hair and testicle development. Linear regression was utilised to compare the effects of WHtR and body mass index (BMI) on sex development indicators. Results 25.98% and 38.58% of boys with precocious puberty were respectively accompanied by obesity (OR=2.15, 95% CI=1.31 to 3.50) or central obesity (OR=2.10, 95% CI=1.46 to 3.03); meanwhile, 13.86% and 29.42% of girls with precocious puberty were respectively accompanied by obesity (OR=9.00, 95% CI=5.60 to 14.46) or central obesity (OR=5.40, 95% CI=4.10 to 7.12). The median ages of breast, pubic hair and testicle development decreased with BMI increase and median ages of thelarche and testicular development rather than pubarche were earlier in children with central obesity. Conclusions Earlier pubertal development was positively associated with obesity and central obesity in Chinese children.
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影响因子：
5
作者：
Daniels, SR;Khoury, PR;Morrison, JA
通讯作者：
Morrison, JA
影响因子：
3.5
作者：
Tanita, M;Matsunaga, J;Tomita, Y
通讯作者：
Tomita, Y
性成熟提前、中心性肥胖以及随后的青春期后期超重。对 1605 名挪威青少年男孩和女孩进行为期四年的跟踪调查：Young HUNT 研究。
影响因子：
4.5
作者：
Bratberg GH;Nilsen TI;Holmen TL;Vatten LJ
通讯作者：
Vatten LJ
影响因子：
12.7
作者：
Adair, LS;Gordon-Larsen, P
通讯作者：
Gordon-Larsen, P
影响因子：
5.1
作者：
Biro, FM;Lucky, AW;Morrison, JA
通讯作者：
Morrison, JA