Long-term Effects of Calcium β-Hydroxy-β-Methylbutyrate and Vitamin D3 Supplementation on Muscular Function in Older Adults With and Without Resistance Training: A Randomized, Double-blind, Controlled Study.
Long-term Effects of Calcium β-Hydroxy-β-Methylbutyrate and Vitamin D3 Supplementation on Muscular Function in Older Adults With and Without Resistance Training: A Randomized, Double-blind, Controlled Study.
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DOI：
10.1093/gerona/glaa218
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发表时间：
2020-10-15
期刊：
影响因子：
--
通讯作者：
Sharp RL
中科院分区：
文献类型：
--
作者：
Rathmacher JA;Pitchford LM;Khoo P;Angus H;Lang J;Lowry K;Ruby C;Krajek AC;Fuller JC;Sharp RL
这项研究的主要目的是确定补充β-羟基-β-甲基丁酸钙(HMB)和维生素D3(D)是否会增强老年人的肌肉功能和力量。60岁以上、循环25-羟基维生素D(25OH-D)水平不足的老年人参加了一项为期12个月的双盲对照研究。研究参与者被随机分配到包括：(A)对照组+不锻炼，(B)HMB+D+不锻炼，(C)对照组+锻炼，和(D)HMB+D+锻炼的处理。这项研究在12个月的时间里通过多项测量对117名参与者进行了评估，包括身体成分、力量、功能和问卷。非运动组6个月时HMB+D组瘦体重(0.44±0.2 7 kg，HMB+D组比−组0.33±0.2 8 kg，对照组，p<；0.0 5)明显改善。在非运动者中，补充HMB+D的参与者在3个月、10.9±5.7Nm和−5.2±5.9Nm时膝关节伸展峰值扭矩(60°/S)的改善显著高于未补充组(p=0.04)。综合了握力、起身、起身和走动测量的变化，开发了一个综合功能指数。HMB+D+不运动组在3个月(p=0.03)、6个月(p=0.04)和12个月(p=0.04)时的功能指数显著高于对照组+不运动组。补充HMB+D并未进一步改善运动组内的功能指数。这项研究证明了补充HMB和维生素D3在增强老年人肌肉力量和身体功能方面的潜力，即使是在没有参加运动训练计划的人中也是如此。
The primary aim of this study was to determine whether supplementation with calcium β-hydroxy-β-methylbutyrate (HMB) and vitamin D3 (D) would enhance muscle function and strength in older adults. Older adults over 60 years of age with insufficient circulating 25-hydroxy-vitamin D (25OH-D) levels were enrolled in a double-blinded controlled 12-month study. Study participants were randomly assigned to treatments consisting of: (a) Control + no exercise, (b) HMB+D + no exercise, (c) Control + exercise, and (d) HMB+D + exercise. The study evaluated 117 participants via multiple measurements over the 12 months that included body composition, strength, functionality, and questionnaires. HMB+D had a significant benefit on lean body mass within the nonexercise group at 6 months (0.44 ± 0.27 kg, HMB+D vs −0.33 ± 0.28 kg, control, p < .05). In nonexercisers, improvement in knee extension peak torque (60°/s) was significantly greater in HMB+D-supplemented participants than in the nonsupplemented group (p = .04) at 3 months, 10.9 ± 5.7 Nm and −5.2 ± 5.9 Nm, respectively. A composite functional index, integrating changes in handgrip, Get Up, and Get Up and Go measurements, was developed. HMB+D + no exercise resulted in significant increases in the functional index compared with those observed in the control + no exercise group at 3 (p = .03), 6 (p = .04), and 12 months (p = .04). Supplementation with HMB+D did not further improve the functional index within the exercising group. This study demonstrated the potential of HMB and vitamin D3 supplementation to enhance muscle strength and physical functionality in older adults, even in individuals not engaged in an exercise training program.
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作者：
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通讯作者：
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影响因子：
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作者：
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DOI：
10.1016/j.jamda.2016.08.009
发表时间：
2016-11-01
影响因子：
7.6
作者：
Cramer, Joel T.;Cruz-Jentoft, Alfonso J.;Mustad, Vikkie A.
通讯作者：
Mustad, Vikkie A.