Effects of ethanol: I. Acute metabolic tolerance and ethnic differences.
Effects of ethanol: I. Acute metabolic tolerance and ethnic differences.
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乙醇的影响： I. 急性代谢耐受和种族差异。
DOI：
10.1111/j.1530-0277.1984.tb05844.x
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
McClearn,GE
中科院分区：
文献类型：
--
作者：
Wilson,JR;Erwin,VG;McClearn,GE
45名年轻男性被给予初始剂量的乙醇，以达到血液酒精浓度（BAC）为100 mg乙醇/ 100 ml血液。使用呼气分析，计算几小时内的乙醇清除率。当每个个体的BAC水平达到其峰值BAC水平的一半（约50 mg%）时，给予第二剂乙醇，剂量为初始剂量的45%，并再次测定清除率。在每次乙醇给药后分别估计吸收时间、峰值BAC、分布容积、清除率和其他代谢参数。按照预期，峰1和峰2之间无显著差异;但是，第2次给药后清除率（β60）显著增加。我们将这种现象称为急性乙醇代谢耐受（AMTE）。当样本按种族分层时，有一种趋势，即东方血统的男性比高加索或波利尼西亚血统的男性更快地耐受药物。数据还表明，先前的饮酒史可能对清除率有影响，尽管这因种族而异。使用两种不同的方法估计分布容积（V）。获得的单独估计值之间的相关性很差，这可能表明需要开发更准确的方法来估计V。
Forty‐five young men were given an initial dose of ethanol calculated to achieve a blood alcohol concentration (BAC) of 100 mg of ethanol/ 100 ml of blood. Using breath analysis, the rates of ethanol clearance were calculated over a period of a few hours. When each individual reached a BAC level exactly one‐half (about 50 mg%) that seen at his peak BAC, he was given a second dose of ethanol amounting to 45% of his initial dose, and the clearance rate was again determined.Estimates of absorption time, peak BAC, volume of distribution, clearance rate, and other metabolic parameters were made separately following each dose of ethanol. As intended, there was no significant difference between peak 1 and peak 2; however, there was a significant increase in clearance rate (β60) after dose 2. We term this phenomenon acute metabolic tolerance to ethanol (AMTE).When the sample was stratified by ethnicity, there was a trend for men of Oriental ancestry to dear the drug at a faster rate than was the case for men of Caucasian or Polynesian ancestry. The data also indicated that prior drinking history may have had an effect on clearance rate, though this differed by ethnicity. Two different methods for estimating volume of distribution(V)were used. The correlation between the separate estimates obtained was poor, and is probably an indication of the need for development of more accurate methods for estimatingV.
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DOI：
10.15288/jsa.1981.42.547
发表时间：
1981-01-01
期刊：
JOURNAL OF STUDIES ON ALCOHOL
影响因子：
--
作者：
WATSON, PE;WATSON, ID;BATT, RD
通讯作者：
BATT, RD
DOI：
10.15288/jsa.1983.44.1093
发表时间：
1983
期刊：
Journal of studies on alcohol
影响因子：
--
作者：
Wilson,JR;Erwin,VG
通讯作者：
Erwin,VG
乙醇的药代动力学：综述。
DOI：
10.1111/j.1530-0277.1980.tb04785.x
发表时间：
1980
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
P. Wilkinson
通讯作者：
P. Wilkinson
比较酒精对因乙醇睡眠时间差异而选择性饲养的小鼠的影响。
DOI：
--
发表时间：
1974
期刊：
Life Science
影响因子：
--
作者：
Warren D.W. Heston;V. Erwin;S. M. Anderson;Howard Robbins
通讯作者：
Howard Robbins
DOI：
10.15288/jsa.1980.41.861
发表时间：
1980-01-01
期刊：
JOURNAL OF STUDIES ON ALCOHOL
影响因子：
--
作者：
SHULTZ, J;WEINER, H;WESTCOTT, J
通讯作者：
WESTCOTT, J