Promise of resveratrol for easing status epilepticus and epilepsy.
Promise of resveratrol for easing status epilepticus and epilepsy.
复制标题
白藜芦醇的癫痫状态和癫痫病的承诺。
DOI：
10.1016/j.pharmthera.2011.04.008
复制
发表时间：
2011-09
影响因子：
13.5
通讯作者：
Shetty, Ashok K.
中科院分区：
文献类型：
--
作者：
Shetty, Ashok K.
关键词：
白藜芦醇（RESV; 3，5，4 ′-三羟基芪），一种天然存在的植物抗毒素，在红葡萄和红葡萄酒的果皮中发现了高浓度。RESV介导广泛的生物活性，包括延长寿命、抗缺血、抗癌、抗病毒、抗衰老和抗炎特性。对几种脑损伤动物模型的研究表明，RESV是一种有效的神经保护化合物。外周给药后进入大脑的能力和对大脑或身体没有不良影响是吸引使用该化合物作为脑损伤或神经退行性疾病的治疗的其他特征。本文综述了RESV在治疗急性癫痫发作、预防急性癫痫发作或癫痫持续状态诱发的慢性癫痫发展、缓解以自发性反复发作和认知功能障碍为特征的慢性癫痫方面的应用前景。首先，讨论了RESV对正常大脑的各种有益作用，为考虑在急性癫痫发作和癫痫的管理中使用RESV治疗提供了依据。接下来，急性癫痫发作或癫痫持续状态对海马的不利影响，以及癫痫持续状态后海马变化对慢性癫痫和认知功能障碍发生的影响进行了总结。最后一部分评估了使用RESV作为神经保护化合物对抗癫痫发作的研究，并提出了在临床应用RESV预防癫痫持续状态或头部损伤后慢性癫痫和认知功能障碍发展之前迫切需要的研究。
Resveratrol (RESV; 3,5,4′-tri-hydroxy stilbene), a naturally occurring phytoalexin, is found at a high concentration in the skin of red grapes and red wine. RESV mediates a wide-range of biological activities, which comprise an increased life span, anti-ischemic, anti-cancer, antiviral, anti-aging and anti-inflammatory properties. Studies in several animal prototypes of brain injury suggest that RESV is an effective neuroprotective compound. Ability to enter the brain after a peripheral administration and no adverse effects on the brain or body are other features that are appealing for using this compound as a therapy for brain injury or neurodegenerative diseases. The goal of this review is to discuss the promise of RESV for treating acute seizures, preventing the acute seizure or status epilepticus induced development of chronic epilepsy, and easing the chronic epilepsy typified by spontaneous recurrent seizures and cognitive dysfunction. First, the various beneficial effects of RESV on the normal brain are discussed to provide a rationale for considering RESV treatment in the management of acute seizures and epilepsy. Next, the detrimental effects of acute seizures or status epilepticus on the hippocampus and the implications of post-status epilepticus changes in the hippocampus towards the occurrence of chronic epilepsy and cognitive dysfunction are summarized. The final segment evaluates studies that have used RESV as a neuroprotective compound against seizures, and proposes studies that are critically needed prior to the clinical application of RESV as a prophylaxis against the development of chronic epilepsy and cognitive dysfunction after an episode of status epilepticus or head injury.
登录
查看更多内容
影响因子：
2.2
作者：
Bernard, C;Esclapez, M;Bernard, C
通讯作者：
Bernard, C
影响因子：
2.2
作者：
André, V;Ferrandon, A;Nehlig, A
通讯作者：
Nehlig, A
影响因子：
2.8
作者：
Balestrazzi, Alma;Bonadei, Martina;Carbonera, Daniela
通讯作者：
Carbonera, Daniela
影响因子：
2.6
作者：
Alessio, A;Damasceno, BP;Cendes, F
通讯作者：
Cendes, F
影响因子：
3.9
作者：
Chung, Sangwoon;Yao, Hongwei;Caito, Samuel;Hwang, Jae-Woong;Arunachalam, Gnanapragasam;Rahman, Irfan
通讯作者：
Rahman, Irfan