The association between insulin resistance, metabolic variables, and depressive symptoms in Mexican-American elderly: A population-based study.
The association between insulin resistance, metabolic variables, and depressive symptoms in Mexican-American elderly: A population-based study.
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墨西哥裔美国人老年人的胰岛素抵抗，代谢变量和抑郁症状之间的关联：基于人群的研究。
DOI：
10.1002/gps.4792
复制
发表时间：
2018-03
影响因子：
4
通讯作者：
McCormick J
中科院分区：
文献类型：
--
作者：
Diniz BS;Fisher-Hoch S;McCormick J
抑郁症状在患有肥胖症和糖尿病的老年人中很常见。尽管如此，这种关联的机制尚不清楚，但可能涉及胰岛素级联信号的变化。我们的目的是调查的关联，和潜在的介质，肥胖，胰岛素抵抗和抑郁症状之间的老年人从一个同质队列的墨西哥裔美国人。我们纳入了总共500名在卡梅隆县健康研究中评估的墨西哥裔美国老年人。我们使用流行病学调查中心抑郁量表（CES-D）评估抑郁症状。中心性肥胖是由腰围定义的。用HOMA-IR指数评价胰岛素抵抗。通过单变量和多变量回归分析，我们估计了肥胖、胰岛素抵抗和抑郁症状之间的关系。在未校正回归分析中，HOMA-IR（未标准化β=0.31±0.12，p=0.007）、腰围（未标准化β=0.066±0.0.028，p=0.017）和Hb 1Ac水平（未标准化β=0.52±0.24，p=0.03）与CES-D评分显著相关。在多变量分析中控制社会人口统计学和临床变量后，HOMA-IR和CES-D的相关性仍具有统计学显著性（非标准化β=0.28±0.11，p=0.01）。我们的研究结果表明，抑郁症状与老年墨西哥裔美国人的胰岛素抵抗有关。此外，较差的血糖控制和肥胖是这种关系的重要介质。需要进一步的研究来评估增加胰岛素敏感性的干预措施是否也可以减少这一人群的抑郁症状。
Depressive symptoms are common among older adults with obesity and diabetes. Nonetheless, the mechanisms for this association are not clear, but may involve changes in the insulin cascade signaling. We aimed to investigate the association, and potential mediators, between obesity, insulin resistance, and depressive symptoms among older adults from a homogenous cohort of Mexican-Americans. We included a total of 500 Mexican-American older adults assessed in the Cameron County Health Study. We evaluated depressive symptoms using the Center for Epidemiologic Survey Depression Scale (CES-D). Central obesity was definied by waist circumference. Insulin resistance was evaluated by the HOMA-IR index. We estimated the association between obesity, insulin resistance, and depressive symptoms by carrying out univariate and multivariate regression analyses. In unadjusted regression analysis, HOMA-IR (unstandardized β=0.31±0.12, p=0.007), waist circumference (unstandardized β=0.066±0.0.028, p=0.017), and Hb1Ac levels (unstandardized β=0.52±0.24, p=0.03) were significantly associated with CES-D scores. The association of HOMA-IR and CES-D remained statistically significant after controlling for socio-demographic and clinical variables in multivariate analysis (unstandardized β=0.28±0.11, p=0.01). Our results suggest that depressive symptoms are associated with insulin resistance in older Mexican-American adults. In addition, poorer glucose control and obesity are important mediators of this relationship. Additional studies are needed to evaluate whether interventions that increase insulin sensitivity can also reduce depressive symptoms in this population.
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影响因子：
11
作者：
Taylor, W. D.;Aizenstein, H. J.;Alexopoulos, G. S.
通讯作者：
Alexopoulos, G. S.
DOI：
10.1016/j.bbadis.2013.05.017
发表时间：
2014-03
影响因子：
6.2
作者：
Lee, Byung-Cheol;Lee, Jongsoon
通讯作者：
Lee, Jongsoon
影响因子：
3.7
作者：
Wu S;Fisher-Hoch SP;Reininger B;McCormick JB
通讯作者：
McCormick JB
影响因子：
5.4
作者：
Laing ST;Smulevitz B;Vatcheva KP;Rahbar MH;Reininger B;McPherson DD;McCormick JB;Fisher-Hoch SP
通讯作者：
Fisher-Hoch SP
影响因子：
4.8
作者：
Diniz, Breno Satler;Lin, Chien-Wei;Butters, Meryl A.
通讯作者：
Butters, Meryl A.