In situ imaging of metals in cells and tissues.
In situ imaging of metals in cells and tissues.
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DOI：
10.1021/cr900223a
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发表时间：
2009-10
期刊：
影响因子：
62.1
通讯作者：
Fahrni, Christoph J.
中科院分区：
文献类型：
--
作者：
McRae, Reagan;Bagchi, Pritha;Sumalekshmy, S.;Fahrni, Christoph J.
Approximately one third of the human proteome contains metal cations, either in the form of cofactors with catalytic functions or as structural support elements. 1, 2 To guarantee a proper maintenance of this metal ion pool, both at the cellular and at whole organism levels, nature has evolved a highly sophisticated machinery comprised of a complex interplay between DNA, proteins, and biomolecules. 3 Over the past decades, a steadily growing number of diseases have been identified that are characterized by metal imbalance in cells and tissues. Among the most prominent examples rank Alzheimer’s disease and Parkinson’s disease, two neurodegenerative disorders that involve abnormal accumulation of transition metals in brain tissue. 4 While some progress has been made in understanding the molecular basis of these disorders, many important questions remain unanswered. For example, little is known about the cellular structures that are involved in transiently storing metal ions prior to their incorporation into metalloproteins or the fate of metal ions upon protein degradation. An important first step toward unraveling the regulatory mechanisms involved in trace metal transport, storage, and distribution represents the identification and quantification of the metals, ideally in context of their native physiological environment in tissues, cells, or even at the level of individual organelles and subcellular compartments.
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影响因子：
15
作者：
Alderden, Rebecca A.;Mellor, Howard R.;Hambley, Trevor W.
通讯作者：
Hambley, Trevor W.
影响因子：
3
作者：
Arora, Manish;Kennedy, Brendan J.;Chan, Sheena W. Y.
通讯作者：
Chan, Sheena W. Y.
影响因子：
64.5
作者：
ADACHI, Y;LUKE, M;LAEMMLI, UK
通讯作者：
LAEMMLI, UK
DOI：
10.1016/j.jtemb.2004.07.001
发表时间：
2004-01-01
影响因子：
3.5
作者：
Arora, M;Chan, SWY;Walker, DM
通讯作者：
Walker, DM
影响因子：
5.2
作者：
Atilgan, Serdar;Ozdemir, Tugba;Akkaya, Engin U.
通讯作者：
Akkaya, Engin U.