Vitamin D and family history of hypertension in relation to hypertension status among college students.
Vitamin D and family history of hypertension in relation to hypertension status among college students.
复制标题
DOI：
10.1038/s41371-021-00577-6
复制
发表时间：
2022-09
影响因子：
2.7
通讯作者：
Wilson, Robin Taylor
中科院分区：
文献类型：
--
作者：
Cuffee, Yendelela L.;Wang, Ming;Geyer, Nathaniel R.;Saxena, Sangeeta;Akuley, Suzanne;Jones, Lenette;Wilson, Robin Taylor
高血压和维生素D浓度具有遗传成分，尽管这些因素在年轻人中尚未研究。本研究的目的是调查年轻成年人中高血压的风险与高血压家族史，调整维生素D的状态。研究人员测量了398名年龄在18-35岁之间的人的静息血压（BP），并根据2017年美国心脏协会标准进行分类。采用液相色谱串联质谱法（LC-MS/MS）测定血浆维生素D代谢物（25（OH）D3; 24，25（OH）2D 3; 1，25（OH）2D 3）浓度。逐步logistic回归用于选择协变量。参与者的平均年龄为21岁，30.3%患有高血压，几乎所有人都不知道自己的高血压状况（90.7%）。与无父母病史的受试者相比，父母双方均患有高血压的受试者的高血压校正比值比（AOR）升高（AOR = 4.5，95%CI：1.70-11.76），校正了性别、体重指数、体力活动和血浆25（OH）D3。收缩期高血压（SH）的结果相似，但更极端（双亲AOR = 7.1，95% CI：2.82，17.66），尽管二羟基代谢物（1，25（OH）2D 3和24，25（OH）2D 3）具有显著性。无论维生素D状况如何，双亲病史和高血压状况都有很强的独立相关性。高血压在近三分之一的样本中普遍存在，并强调了对年轻人进行有针对性的预防的必要性。
Hypertension and vitamin D concentrations have heritable components, although these factors remain uninvestigated in young adults. The objective of this study was to investigate hypertension risk among young adults with respect to family history of hypertension, adjusting for vitamin D status. Resting blood pressure (BP) was measured in 398 individuals aged 18–35 and classified according to the 2017 American Heart Association criteria. Plasma vitamin D metabolite (25(OH)D3; 24,25(OH)2D3; 1,25(OH)2D3) concentrations were determined using liquid chromatography tandem mass spectrometry (LC-MS/MS). Stepwise logistic regression was used to select covariates. Participants' mean age was 21, 30.3% had hypertension, and nearly all unaware of their hypertensive status (90.7%). Compared with no parental history, the adjusted odds ratio (AOR) for hypertension was elevated among participants with two parents having hypertension (AOR = 4.5, 95% CI: 1.70–11.76), adjusting for sex, body mass index, physical activity, and plasma 25(OH)D3. Results for systolic hypertension (SH) were similar but more extreme (two parents AOR = 7.1, 95% CI: 2.82, 17.66), although dihydroxy metabolites (1,25(OH)2D3 and 24,25(OH)2D3) were significant. There was a strong, independent association with dual parental history and hypertension status, regardless of vitamin D status. Hypertension was prevalent in nearly one-third of the sample and underscores the need for targeted prevention for young adults.
登录
查看更多内容
影响因子：
1.3
作者：
Everett B;Zajacova A
通讯作者：
Zajacova A
影响因子：
5.6
作者：
Diaz, Keith M.;Shimbo, Daichi
通讯作者：
Shimbo, Daichi
影响因子：
5.4
作者：
Andersen LB;Przybyl L;Haase N;von Versen-Höynck F;Qadri F;Jørgensen JS;Sorensen GL;Fruekilde P;Poglitsch M;Szijarto I;Gollasch M;Peters J;Muller DN;Christesen HT;Dechend R
通讯作者：
Dechend R
影响因子：
4.9
作者：
Goldstein, Iris B.;Shapiro, David;Weiss, Robert E.
通讯作者：
Weiss, Robert E.
影响因子：
5
作者：
Khalili, Hossein;Talasaz, Azita Hajhossein;Salarifar, Mojtaba
通讯作者：
Salarifar, Mojtaba