Dynamic variation in forebrain estradiol levels during song learning.
Dynamic variation in forebrain estradiol levels during song learning.
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DOI：
10.1002/dneu.22228
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发表时间：
2015-03
影响因子：
3
通讯作者：
Remage-Healey, Luke
中科院分区：
文献类型：
--
作者：
Chao, Andrew;Paon, Ashley;Remage-Healey, Luke
雌激素在发育过程中塑造大脑回路，局部合成雌激素的能力对性别分化和早期学习过程中回路的急剧调制都有影响。最近优化的一种方法来检测和量化体内大脑雌激素的波动，为探索大脑雌激素的产生如何在发育过程中促进分化和神经调节提供了直接的手段。在这里，我们使用这种方法来检验这样的假设，即在幼年斑马雀的歌曲学习期间，神经雌激素是性别分化的，并且对歌曲辅导(通过被动的视频/音频回放)具有动态响应。我们的结果表明，在男性化的早期关键窗口，男性和女性的尾侧前脑中的基线神经雌二醇水平没有差异。相反，我们观察到，随着动物接近性成熟，在亚成体阶段出现的基线神经雌二醇在雄性和雌性之间存在显著差异。其次，我们观察到，与成人相比，青少年在被动歌曲辅导期间波动的神经雌二醇水平表现出明显不同的特征。具体地说，在幼年男性和女性中，尾侧前脑中的神经雌激素在家教歌曲暴露后(而不是在家教歌曲暴露期间)都会升高，这表明在早期巩固家教歌曲记忆方面发挥了重要作用。这些结果进一步揭示了在感觉/认知任务中对局部神经雌激素波动的昼夜节律影响。综上所述，这些发现揭示了幼年动物大脑雌激素合成的几个意想不到的特征，这些特征可能对二次男性化以及最近感觉经验的巩固有影响。
Estrogens shape brain circuits during development, and the capacity to synthesize estrogens locally has consequences for both sexual differentiation and the acute modulation of circuits during early learning. A recently-optimized method to detect and quantify fluctuations in brain estrogens in vivo provides a direct means to explore how brain estrogen production contributes to both differentiation and neuromodulation during development. Here, we use this method to test the hypothesis that neuroestrogens are sexually-differentiated as well as dynamically responsive to song tutoring (via passive video/audio playback) during the period of song learning in juvenile zebra finches. Our results show that baseline neuroestradiol levels in the caudal forebrain do not differ between males and females during an early critical masculinization window. Instead, we observe a prominent difference between males and females in baseline neuroestradiol that emerges during the subadult stage as animals approach sexual maturity. Second, we observe that fluctuating neuroestradiol levels during periods of passive song tutoring exhibit a markedly different profile in juveniles as compared to adults. Specifically, neuroestrogens in the caudal forebrain are elevated following (rather than during) tutor song exposure in both juvenile males and females, suggesting an important role for the early consolidation of tutor song memories. These results further reveal a circadian influence on the fluctuations in local neuroestrogens during sensory/cognitive tasks. Taken together, these findings uncover several unexpected features of brain estrogen synthesis in juvenile animals that may have implications for secondary masculinization as well as the consolidation of recent sensory experiences.
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影响因子：
3.5
作者：
Duncan, Kelli A.;Walters, Bradley J.;Saldanha, Colin J.
通讯作者：
Saldanha, Colin J.
影响因子：
4.8
作者：
Gréco, B;Allegretto, EA;Blaustein, JD
通讯作者：
Blaustein, JD
影响因子：
2.7
作者：
Gong, A;Freking, FW;Arnold, AP
通讯作者：
Arnold, AP
影响因子：
64.8
作者：
Derégnaucourt, S;Mitra, PP;Tchernichovski, O
通讯作者：
Tchernichovski, O
DOI：
10.1523/jneurosci.0763-09.2009
发表时间：
2009-07-22
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Gottsch ML;Navarro VM;Zhao Z;Glidewell-Kenney C;Weiss J;Jameson JL;Clifton DK;Levine JE;Steiner RA
通讯作者：
Steiner RA