Retinal expression of small non-coding RNAs in a murine model of proliferative retinopathy.
Retinal expression of small non-coding RNAs in a murine model of proliferative retinopathy.
复制标题
DOI：
10.1038/srep33947
复制
发表时间：
2016-09-22
影响因子：
4.6
通讯作者：
Chen J
中科院分区：
文献类型：
--
作者：
Liu CH;Wang Z;Sun Y;SanGiovanni JP;Chen J
Ocular neovascularization is a leading cause of blindness in proliferative retinopathy. Small non-coding RNAs (sncRNAs) play critical roles in both vascular and neuronal development of the retina through post-transcriptional regulation of target gene expression. To identify the function and therapeutic potential of sncRNAs in retinopathy, we assessed the expression profile of retinal sncRNAs in a mouse model of oxygen-induced retinopathy (OIR) with pathologic proliferation of neovessels. Approximately 2% of all analyzed sncRNAs were significantly altered in OIR retinas compared with normoxic controls. Twenty three microRNAs with substantial up- or down-regulation were identified, including miR-351, -762, -210, 145, -155, -129-5p, -150, -203, and -375, which were further analyzed for their potential target genes in angiogenic, hypoxic, and immune response-related pathways. In addition, nineteen small nucleolar RNAs also revealed differential expression in OIR retinas compared with control retinas. A decrease of overall microRNA expression in OIR retinas was consistent with reduced microRNA processing enzyme Dicer, and increased expression of Alu element in OIR. Together, our findings elucidated a group of differentially expressed sncRNAs in a murine model of proliferative retinopathy. These sncRNAs may exert critical post-transcriptional regulatory roles in regulating pathological neovascularization in eye diseases.
登录
查看更多内容
DOI：
10.1038/jcbfm.2008.157
发表时间：
2009-04
期刊：
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
影响因子：
--
作者：
通讯作者：
--
影响因子：
--
作者：
Arora A;Guduric-Fuchs J;Harwood L;Dellett M;Cogliati T;Simpson DA
通讯作者：
Simpson DA
影响因子：
4.4
作者：
Karali M;Peluso I;Gennarino VA;Bilio M;Verde R;Lago G;Dollé P;Banfi S
通讯作者：
Banfi S
DOI：
10.1056/nejmra1208129
发表时间：
2012-12-27
期刊：
The New England journal of medicine
影响因子：
--
作者：
Hartnett ME;Penn JS
通讯作者：
Penn JS
影响因子：
15.9
作者：
Im HI;Kenny PJ
通讯作者：
Kenny PJ