Alpha and beta EEG power reflects L-dopa acute administration in parkinsonian patients.
Alpha and beta EEG power reflects L-dopa acute administration in parkinsonian patients.
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DOI：
10.3389/fnagi.2014.00302
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发表时间：
2014
影响因子：
4.8
通讯作者：
Vernieri F
中科院分区：
文献类型：
--
作者：
Melgari JM;Curcio G;Mastrolilli F;Salomone G;Trotta L;Tombini M;di Biase L;Scrascia F;Fini R;Fabrizio E;Rossini PM;Vernieri F
目的：评价急性左旋多巴给药对认知功能保留的帕金森病患者闭眼静息状态脑电图（EEG）活动的影响。方法：我们检查了24例右利手患者诊断为简单的可能帕金森病（PD）。每例患者在口服左旋多巴甲酯/卡比多巴250/25 mg之前和之后60 min接受统一帕金森病评定量表（Unified Parkinson's Disease Rating Scale，CAFRS）-第III部分评估。静息状态下闭眼EEG数据记录前和后L-多巴负荷。绝对EEG功率值计算在每个头皮推导的Delta，Theta，Alpha和Beta频带。将EEG RS评分（总体和子量表评分）和EEG数据（每个头皮衍生物的不同频带的功率值）提交给统计分析，以比较L-多巴治疗前和治疗后的情况。最后，对EEG频谱内容与EEG评分进行相关性分析。结果：从脑电功率谱分析来看，服用左旋多巴后，δ和θ频段的差异无统计学意义。相反，α和β节律显着增加中央顶叶头皮衍生，作为一个功能的左旋多巴管理。相关性分析表明，中央顶叶区的β功率增加与WESTERS分项评分（手臂僵硬和运动迟缓）之间存在显著负相关。α波带增加与静止性震颤之间也存在轻微的显著负相关。结论：假设左旋多巴摄入后EEG功率谱的显著变化可能与多巴胺能机制有关，我们的研究结果与多巴胺能缺陷网络与非痴呆PD患者静息时皮质振荡异常有关的假设一致。
Aim: To evaluate the effect of an acute L-dopa administration on eye-closed resting state electroencephalographic (EEG) activity of cognitively preserved Parkinsonian patients. Methods: We examined 24 right-handed patients diagnosed as uncomplicated probable Parkinson’s disease (PD). Each patient underwent Unified Parkinson’s Disease Rating Scale (UPDRS)-part-III evaluation before and 60 min after an oral load of L-dopa-methyl-ester/carbidopa 250/25 mg. Resting condition eyes-closed EEG data were recorded both pre- and post L-dopa load. Absolute EEG power values were calculated at each scalp derivation for Delta, Theta, Alpha and Beta frequency bands. UPDRS scores (both global and subscale scores) and EEG data (power values of different frequency bands for each scalp derivation) were submitted to a statistical analysis to compare Pre and Post L-Dopa conditions. Finally, a correlation analysis was carried out between EEG spectral content and UPDRS scores. Results: Considering EEG power spectral analysis, no statistically significant differences arose on Delta and Theta bands after L-dopa intake. Conversely, Alpha and Beta rhythms significantly increased on centro-parietal scalp derivations, as a function of L-dopa administration. Correlation analysis indicated a significant negative correlation between Beta power increase on centro-parietal areas and UPDRS subscores (Rigidity of arms and Bradykinesia). A minor significant negative correlation was also found between Alpha band increase and resting tremor. Conclusions: Assuming that a significant change in EEG power spectrum after L-dopa intake may be related to dopaminergic mechanisms, our findings are consistent with the hypothesis that dopaminergic defective networks are implicated in cortical oscillatory abnormalities at rest in non-demented PD patients.
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DOI：
10.1073/pnas.0308538101
发表时间：
2004-06-29
影响因子：
11.1
作者：
Brovelli, A;Ding, MZ;Bressler, SL
通讯作者：
Bressler, SL
影响因子：
14.5
作者：
Catalan, MJ;Ishii, K;Hallett, M
通讯作者：
Hallett, M
影响因子：
14.5
作者：
Fellows, SJ;Noth, J;Schwarz, M
通讯作者：
Schwarz, M
影响因子：
56.9
作者：
Buschman, Timothy J.;Miller, Earl K.
通讯作者：
Miller, Earl K.
影响因子：
8.6
作者：
Grosset, K;Needleman, F;Grosset, D
通讯作者：
Grosset, D