Mechanisms Orchestrating Mitochondrial Dynamics for Energy Homeostasis.
Mechanisms Orchestrating Mitochondrial Dynamics for Energy Homeostasis.
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DOI：
10.1016/j.jmb.2018.07.027
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发表时间：
2018-10-19
影响因子：
5.6
通讯作者：
Pekkurnaz G
中科院分区：
文献类型：
--
作者：
Yu SB;Pekkurnaz G
为了维持体内平衡，每个细胞必须不断监测其能量水平，并根据代谢需求以ATP的形式适当调整能量的产生速率。这种能量需求的持续满足取决于细胞感知、代谢和将营养物质转化为化学能的能力。线粒体是许多细胞类型的主要能量转换场所。细胞代谢状态决定了线粒体的大小、形状、功能和位置。线粒体形状从单一的离散细胞器到细胞内相互连接的网状网络。线粒体对代谢线索的形态适应是由转运、融合、裂变和质量控制等动态事件促进的。通过改变其在细胞质内的动态和战略定位，线粒体执行关键功能，并积极参与细胞器间的相互作用，协助代谢物转移、降解和生物发生。线粒体动力学已成为一个活跃的研究领域，因为它在癌症、代谢性疾病和神经系统疾病中具有特殊的重要性。在这篇综述中，我们将重点介绍参与线粒体动力学调控的分子途径及其在维持能量稳态中的作用。
To maintain homeostasis, every cell must constantly monitor its energy level and appropriately adjust energy, in the form of ATP, production rates based on metabolic demand. Continuous fulfillment of this energy demand depends on the ability of cells to sense, metabolize, and convert nutrients into chemical energy. Mitochondria are the main energy conversion sites for many cell types. Cellular metabolic states dictate the mitochondrial size, shape, function and positioning. Mitochondrial shape varies from singular discrete organelles to interconnected reticular networks within cells. The morphological adaptations of mitochondria to metabolic cues are facilitated by the dynamic events categorized as transport, fusion, fission, and quality control. By changing their dynamics and strategic positioning within the cytoplasm, mitochondria carry out critical functions and also participate actively in inter-organelle cross-talk, assisting metabolite transfer, degradation, and biogenesis. Mitochondrial dynamics has become an active area of research because of its particular importance in cancer, metabolic diseases, and neurological disorders. In this review, we will highlight the molecular pathways involved in the regulation of mitochondrial dynamics and their roles in maintaining energy homeostasis.
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影响因子：
3.7
作者：
Cartoni R;Pekkurnaz G;Wang C;Schwarz TL;He Z
通讯作者：
He Z
影响因子：
--
作者：
Cohen, Yifat;Klug, Yoel Alexander;Schuldiner, Maya
通讯作者：
Schuldiner, Maya
影响因子：
16.2
作者：
Beckervordersandforth R;Ebert B;Schäffner I;Moss J;Fiebig C;Shin J;Moore DL;Ghosh L;Trinchero MF;Stockburger C;Friedland K;Steib K;von Wittgenstein J;Keiner S;Redecker C;Hölter SM;Xiang W;Wurst W;Jagasia R;Schinder AF;Ming GL;Toni N;Jessberger S;Song H;Lie DC
通讯作者：
Lie DC
影响因子：
29
作者：
Civiletto G;Varanita T;Cerutti R;Gorletta T;Barbaro S;Marchet S;Lamperti C;Viscomi C;Scorrano L;Zeviani M
通讯作者：
Zeviani M
DOI：
10.1083/jcb.201401070
发表时间：
2014-09-01
期刊：
The Journal of cell biology
影响因子：
--
作者：
Ashrafi G;Schlehe JS;LaVoie MJ;Schwarz TL
通讯作者：
Schwarz TL