Metabolomic screening of pre-diagnostic serum samples identifies association between α- and γ-tocopherols and glioblastoma risk.
Metabolomic screening of pre-diagnostic serum samples identifies association between α- and γ-tocopherols and glioblastoma risk.
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DOI：
10.18632/oncotarget.9242
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发表时间：
2016-06-14
期刊：
影响因子：
--
通讯作者：
Melin B
中科院分区：
文献类型：
--
作者：
Björkblom B;Wibom C;Jonsson P;Mörén L;Andersson U;Johannesen TB;Langseth H;Antti H;Melin B
胶质母细胞瘤预后差，中位生存期为一年。高剂量电离辐射是唯一确定的外源性风险因素。为了探索胶质母细胞瘤的新的潜在生物学风险因素，我们研究了样本采集后22年内确诊的胶质母细胞瘤患者和未患病对照的预诊断血清样本中代谢物浓度的变化。该研究指出了未来胶质母细胞瘤的潜在生物标志物，由参与抗氧化代谢的9种代谢物（γ-生育酚、α-生育酚、维生素E、维生素E、肌醇、胱氨酸、2-酮基-L-葡萄糖酸、次黄嘌呤和黄嘌呤）组成。我们在未来的胶质母细胞瘤病例中检测到显著更高的α-生育酚（p=0.0018）和γ-生育酚（p=0.0009）血清浓度。与其匹配的对照组相比，病例显示α-和γ-生育酚水平的平均增加倍数显著增加：α-T为1.2（p=0.018），γ-T为1.6（p=0.003）。这些生育酚水平与胶质母细胞瘤的比值比为1.7（α-T，95% CI：1.0-3.0）和2.1（γ-T，95% CI：1.2-3.8）相关。我们的探索性代谢组学研究检测到一组具有抗氧化特性的分子以及氧化应激产生的化合物的血清水平升高。有必要进行进一步的研究，以确认观察到的血清代谢物模式和未来胶质母细胞瘤发展之间的关联。
Glioblastoma is associated with poor prognosis with a median survival of one year. High doses of ionizing radiation is the only established exogenous risk factor. To explore new potential biological risk factors for glioblastoma, we investigated alterations in metabolite concentrations in pre-diagnosed serum samples from glioblastoma patients diagnosed up to 22 years after sample collection, and undiseased controls. The study points out a latent biomarker for future glioblastoma consisting of nine metabolites (γ-tocopherol, α-tocopherol, erythritol, erythronic acid, myo-inositol, cystine, 2-keto-L-gluconic acid, hypoxanthine and xanthine) involved in antioxidant metabolism. We detected significantly higher serum concentrations of α-tocopherol (p=0.0018) and γ-tocopherol (p=0.0009) in future glioblastoma cases. Compared to their matched controls, the cases showed a significant average fold increase of α- and γ-tocopherol levels: 1.2 for α-T (p=0.018) and 1.6 for γ-T (p=0.003). These tocopherol levels were associated with a glioblastoma odds ratio of 1.7 (α-T, 95% CI:1.0-3.0) and 2.1 (γ-T, 95% CI:1.2-3.8). Our exploratory metabolomics study detected elevated serum levels of a panel of molecules with antioxidant properties as well as oxidative stress generated compounds. Additional studies are necessary to confirm the association between the observed serum metabolite pattern and future glioblastoma development.
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影响因子：
5.6
作者：
Ichida K;Amaya Y;Okamoto K;Nishino T
通讯作者：
Nishino T
影响因子：
7.4
作者：
Jiang, Qing
通讯作者：
Jiang, Qing
影响因子：
4.4
作者：
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通讯作者：
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DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
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通讯作者：
HOCHBERG, Y
影响因子：
8.4
作者：
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通讯作者：
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