Characteristic physical traits of first-grade children in the United States with fetal alcohol spectrum disorders (FASD) and associated alcohol and drug exposures.
Characteristic physical traits of first-grade children in the United States with fetal alcohol spectrum disorders (FASD) and associated alcohol and drug exposures.
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美国患有胎儿酒精谱系障碍(FASD)及相关酒精和药物暴露的一年级儿童的特征身体特征。
DOI：
10.1002/ajmg.a.62738
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发表时间：
2022-07
影响因子：
2
通讯作者：
Hoyme, H. Eugene
中科院分区：
文献类型：
--
作者：
May, Philip A.;Hasken, Julie M.;Manning, Melanie A.;Robinson, Luther K.;Abdul-Rahman, Omar;Adam, Margaret P.;Jewett, Tamison;Elliott, Amy J.;Kalberg, Wendy O.;Buckley, David;Hoyme, H. Eugene
关键词：
我们将 131 名患有胎儿酒精谱系障碍 (FASD) 的一年级儿童的生长、身体特征和轻微异常与来自同一人群的典型发育儿童的代表性对照组 (n=1212) 进行了比较。这些数据是从 NIAAA 资助的 FASD 患病率合作组织 (CoFASP) 的三个区域站点收集的。形态异常检查由临床遗传学专家团队进行，FASD 诊断根据修订后的医学研究所指南进行分配，其中包括生长、形态异常、神经行为和孕产妇风险访谈的评估。我们提供了 FASD 连续体中四个诊断类别中每个儿童的 32 项身体特征、轻微异常和畸形评分汇总的详细数据。不同种族或西班牙裔的 FASD 诊断频率几乎没有差异。患有 FASD 的孩子的母亲报告称在怀孕期间使用酒精、烟草 (28.3%) 和其他药物 (14.2%)。在控制烟草和其他药物使用的情况下，风险分析表明，怀孕前每天饮酒 3 杯的女性生出患有 FASD 的孩子的可能性 (p<.001，OR=9.92，95% CI：4.6–21.5) 是那些在怀孕前报告戒酒的女性的 10 倍。
We compared growth, physical features and minor anomalies in 131 first grade children with fetal alcohol spectrum disorders (FASD) to those of a representative comparison group of typically developing children from the same populations (n=1212). The data were collected from three regional sites in the NIAAA-funded Collaboration on FASD Prevalence (CoFASP). Dysmorphology examinations were performed by a team of expert clinical geneticists, and FASD diagnoses were assigned according to the Revised Institute of Medicine Guidelines, which include assessments of growth, dysmorphology, neurobehavior and maternal risk interviews. We present detailed data on 32 physical traits, minor anomalies and a summary dysmorphology score for children within each of the four diagnostic categories in the continuum of FASD. There were few differences in the frequency of FASD diagnoses by race or Hispanic ethnicity. Children with FASD were born to mothers who reported using alcohol, tobacco (28.3%), and other drugs (14.2%) during pregnancy. Controlling for tobacco and other drug use, risk analysis indicated that women with a drinking pattern of 3 drinks per drinking day prior to pregnancy were 10 times more likely (p<.001, OR=9.92, 95% CI: 4.6–21.5) to bear a child with FASD than those who reported abstinence prior to pregnancy.
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DOI：
10.1111/acer.14325
发表时间：
2020-06
期刊：
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
影响因子：
--
作者：
Coles, Claire D.;Kalberg, Wendy;Kable, Julie A.;Tabachnick, Barbara;May, Philip A.;Chambers, Christina D.
通讯作者：
Chambers, Christina D.
影响因子：
5.5
作者：
Denny CH;Acero CS;Terplan M;Kim SY
通讯作者：
Kim SY
影响因子：
8
作者：
Hoyme, H. Eugene;Kalberg, Wendy O.;May, Philip A.
通讯作者：
May, Philip A.
影响因子：
8
作者：
Carter, R. Colin;Jacobson, Joseph L.;Jacobson, Sandra W.
通讯作者：
Jacobson, Sandra W.
影响因子：
1.4
作者：
Caetano R;Vaeth PA;Rodriguez LA
通讯作者：
Rodriguez LA