Murine TMJ loading causes increased proliferation and chondrocyte maturation.
Murine TMJ loading causes increased proliferation and chondrocyte maturation.
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DOI：
10.1177/0022034510390810
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发表时间：
2011-04
影响因子：
7.6
通讯作者：
Wadhwa S
中科院分区：
文献类型：
--
作者：
Sobue T;Yeh WC;Chhibber A;Utreja A;Diaz-Doran V;Adams D;Kalajzic Z;Chen J;Wadhwa S
本研究的目的是探讨强迫开口对小鼠下颌髁头重塑的影响。我们假设强迫张嘴会引起下颌髁软骨的合成代谢反应。将6周龄雌性C57BL/6小鼠分为3组：(1)对照组、(2)0.25 N、(3)0.50 N强制张口。分析基因表达、显微ct及细胞增殖情况。0.5 N的强迫张口导致Pthrp、Sox9和Collagen2a1 mRNA表达显著增加，增殖显著增加，软骨下骨小梁间距显著增加，而0.25 N的强迫张口没有引起任何参数的显著变化。强迫张嘴导致软骨细胞成熟标志物表达增加和软骨下小梁间距增加。
The purpose of this study was to examine the effects of forced mouth opening on murine mandibular condylar head remodeling. We hypothesized that forced mouth opening would cause an anabolic response in the mandibular condylar cartilage. Six-week-old female C57BL/6 mice were divided into 3 groups: (1) control, (2) 0.25 N, and (3) 0.50 N of forced mouth opening. Gene expression, micro-CT, and proliferation were analyzed. 0.5 N of forced mouth opening caused a significant increase in mRNA expression of Pthrp, Sox9, and Collagen2a1, a significant increase in proliferation, and a significant increase in trabecular spacing in the subchondral bone, whereas 0.25 N of forced mouth opening did not cause any significant changes in any of the parameters examined. Forced mouth opening causes an increase in the expression of chondrocyte maturation markers and an increase in subchondral trabecular spacing.
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影响因子：
3
作者：
Chen, J.;Gupta, T.;Barasz, J. A.;Kalajzic, Z.;Yeh, W. -C.;Drissi, H.;Hand, A. R.;Wadhwa, S.
通讯作者：
Wadhwa, S.
影响因子：
7
作者：
Ohno, S.;Schmid, T.;Knudson, W.
通讯作者：
Knudson, W.
影响因子：
3
作者：
Rafferty, Katherine L.;Sun, Zongyang;Herring, Susan W.
通讯作者：
Herring, Susan W.
影响因子：
3
作者：
Lai, Alon;Chow, Daniel H. K.;Pope, Malcolm H.
通讯作者：
Pope, Malcolm H.
影响因子：
2.9
作者：
Kuboki, T;Takenami, Y;Clark, GT
通讯作者：
Clark, GT