A randomized clinical trial of naltrexone and behavioral therapy for problem drinking men who have sex with men.
A randomized clinical trial of naltrexone and behavioral therapy for problem drinking men who have sex with men.
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DOI：
10.1037/a0028615
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发表时间：
2012-10
影响因子：
5.9
通讯作者：
Kranzler, Henry R.
中科院分区：
文献类型：
--
作者：
Morgenstern, Jon;Kuerbis, Alexis N.;Chen, Andrew C.;Kahler, Christopher W.;Bux, Donald A., Jr.;Kranzler, Henry R.
这项研究测试了改良行为自我控制疗法（MBSCT）和纳洛酮（NTX）的比较有效性，以及结合两者的额外好处，在寻求减少但不戒酒的问题饮酒男性（MSM）中。方法：招募参与者（N=200），并将其随机分配到两种药物条件之一，NTX或安慰剂（PBO）和MSBCT或无行为干预，产生四种条件：PBO，NTX，MSBCT和NTX+MSBCT。此外，所有参与者都接受了简短的药物依从性干预。参与者接受了12周的治疗，并在治疗完成后一周进行评估。两个主要结果-标准饮酒量和大量饮酒天数的总和-和一个次要结果-以非危险方式饮酒（NoH）的百分比-被先验地选择。结果：MBSCT对所有三个结局均有显著的主效应（所有ps < .01），但NTX对所有三个结局无显著影响。此外，NTX和MBSCT的组合并不比MSCBT或PBO更有效。有一个显着的相互作用对NoH，这样NTX显着增加的可能性（OR = 3.3），实现一个非危险的饮酒结果相对于PBO。此外，NTX在描述性结果方面比PBO更有效：饮酒的负面后果。在MBSCT中加入NTX没有优势。此外，MBSCT显示出比NTX更强的疗效证据。与此同时，在最低限度的药物依从性干预的背景下，NTX在一个重要的临床指标上比PBO更有效。结果提供了新的信息，以指导治疗问题饮酒，包括在初级保健环境。
This study tested the comparative effectiveness of Modified Behavioral Self-Control Therapy (MBSCT) and naltrexone (NTX), as well as the added benefit of combining the two, in problem drinking men who have sex with men (MSM) seeking to reduce, but not quit drinking. Method: Participants (N=200) were recruited and urn randomized to one of two medication conditions, NTX or placebo (PBO) and either MSBCT or no behavioral intervention, yielding four conditions: PBO, NTX, MSBCT, and NTX+MSBCT. In addition, all participants received a brief medication compliance intervention. Participants were treated for 12 weeks and assessed one week after treatment completion. Two primary outcomes - sum of standard drinks and number of heavy drinking days - and one secondary outcome - percentage of those drinking in a non-hazardous manner (NoH) - were selected a-priori. Results: There was a significant main effect for MBSCT (all ps < .01), but not NTX on all three outcomes. In addition, the combination of NTX and MBSCT was not more effective than either MSCBT or PBO. There was a significant interaction effect on NoH, such that NTX significantly increased the likelihood (OR = 3.3) of achieving a non-hazardous drinking outcome relative to PBO. In addition, NTX was significantly more effective than PBO on a descriptive outcome: negative consequences of drinking. There was no advantage to adding NTX to MBSCT. In addition, MBSCT showed stronger evidence of efficacy than NTX. At the same time, NTX delivered in the context of a minimal medication compliance intervention was significantly more effective than PBO on an important clinical indicator. Results provide new information to guide the treatment of problem drinking, including in primary care settings.
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有针对性的纳曲酮用于饮酒者。
影响因子：
2.9
作者：
Kranzler HR;Tennen H;Armeli S;Chan G;Covault J;Arias A;Oncken C
通讯作者：
Oncken C
DOI：
10.15288/jsa.2004.65.774
发表时间：
2004-11-01
期刊：
JOURNAL OF STUDIES ON ALCOHOL
影响因子：
--
作者：
Carey, KB;Carey, MP;Henson, JM
通讯作者：
Henson, JM
DOI：
10.15288/jsa.2000.61.55
发表时间：
2000-01-01
期刊：
JOURNAL OF STUDIES ON ALCOHOL
影响因子：
--
作者：
Babor, TF;Steinberg, K;Del Boca, F
通讯作者：
Del Boca, F
影响因子：
2.9
作者：
Anton, RF;Moak, DH;Woolson, R
通讯作者：
Woolson, R
影响因子：
4.2
作者：
Carroll, KM;Nich, C;Rounsaville, BJ
通讯作者：
Rounsaville, BJ