Heat shock protein 70 acts as a potential biomarker for early diagnosis of heart failure.
Heat shock protein 70 acts as a potential biomarker for early diagnosis of heart failure.
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热休克蛋白 70 作为心力衰竭早期诊断的潜在生物标志物
DOI：
10.1371/journal.pone.0067964
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Gao W
中科院分区：
文献类型：
--
作者：
Li Z;Song Y;Xing R;Yu H;Zhang Y;Li Z;Gao W
心衰（HF）的早期识别可能有助于疾病修饰治疗，以减少心脏病的进展，甚至逆转它。在我们之前的研究中，我们通过蛋白质组学方法发现了一组可能与新生大鼠心肌细胞肥大有关的热休克蛋白（HSPs）。本研究证实，HSP27和HSP70在体内动物模型心脏重构早期发生了改变。并对222例患者不同阶段的血浆热休克蛋白浓度及其潜在筛查价值进行了评价。采用酶联免疫吸附法检测血浆HSP27、HSP70和HSP90。结果表明，HSP70与HF的严重程度（进展）呈正相关（r = 0.456, p<0.001）。B期HF的ROC曲线下面积为0.601 (p = 0.017)， C期HF的ROC曲线下面积为0.835 （p<0.001）。然而，在本研究中，HSP27和HSP90在HF的任何阶段均未出现显著变化。综上所述，血浆HSP70浓度随着HF的进展而升高，可能作为HF早期诊断的潜在筛选生物标志物。
Early identification for heart failure (HF) may be useful for disease modifying treatment in order to reduce heart disease progression or even to reverse it. In our previous studies, we have revealed a group of heat shock proteins (HSPs) which might be related to neonatal rat cardiomyocyte hypertrophy by proteomic approach. Here, we confirm that HSPs, including HSP27 and HSP70, altered in the early stage of cardiac remodeling in vivo animal model. Furthermore, plasma concentrations of those HSPs and their potential screening value were evaluated at different stages in 222 patient subjects. Plasma HSP27, HSP70 and HSP90 were measured using enzyme-linked immunosorbent assay. Results indicate that HSP70 was positively correlated to the severity (progression) of HF (r = 0.456, p<0.001). The area under the rate of change (ROC) curve was 0.601 (p = 0.017) in patients with stage B HF and 0.835 (p<0.001) in those with stage C HF. However, HSP27 and HSP90 did not display significant changes in any stage of HF in this study. Taken together, plasma concentrations of HSP70 elevated with the progression of HF and might act as a potential screening biomarker for early diagnosis of HF.
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影响因子：
3.1
作者：
Li Zi-jian;Liu Ning;Zhang You-yi
通讯作者：
Zhang You-yi
影响因子：
15.9
作者：
Trost, SU;Omens, JH;Dillmann, WH
通讯作者：
Dillmann, WH
影响因子：
3.8
作者：
Giannessi, Daniela;Colotti, Chiara;Neglia, Danilo
通讯作者：
Neglia, Danilo
DOI：
10.1152/ajpheart.1994.267.5.h1941
发表时间：
1994-11-01
影响因子：
4.8
作者：
CORNELUSSEN, R;SPIERING, W;SNOECKX, LHEH
通讯作者：
SNOECKX, LHEH
DOI：
10.1046/j.1432-1327.2000.01112.x
发表时间：
2000-02-01
期刊：
EUROPEAN JOURNAL OF BIOCHEMISTRY
影响因子：
--
作者：
Stuhlmeier, KM
通讯作者：
Stuhlmeier, KM