Meal schedule influences food restriction-induced locomotor sensitization to methamphetamine.
Meal schedule influences food restriction-induced locomotor sensitization to methamphetamine.
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DOI：
10.1007/s00213-011-2401-6
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发表时间：
2012-02
影响因子：
3.4
通讯作者：
Beckstead, Michael J.
中科院分区：
文献类型：
--
作者：
Sharpe, Amanda L.;Klaus, Joshua D.;Beckstead, Michael J.
Traditional protocols for inducing sensitization to psychostimulants use an intermittent or “binge”-like drug administration, and binge eating behavior is comorbid with drug abuse in humans. Food restriction increases the reinforcing properties and self-administration of many drugs of abuse. The present study tested the hypotheses that (1) food restriction induces sensitization to the locomotor stimulation observed in response to methamphetamine and (2) a binge-like feeding schedule during food restriction produces increased sensitization compared to equally restricted mice fed in three daily meals. Male DBA/2J mice were fed ad libitum or were food restricted to either an 8% or 16% loss of body weight. Additionally, the food-restricted mice were divided into two groups that were fed in either one meal (binge) or three equal-sized meals (meal). After the reduced body weight was stable, mice were tested for locomotor activity following saline and methamphetamine (1 mg/kg) injections. Both 16% body weight loss groups exhibited sensitization to methamphetamine. Opposite to our hypothesis, the 8% meal but not the 8% binge food-restricted group demonstrated locomotor sensitization. Serum corticosterone levels were significantly higher in the meal-fed groups when compared to the binge- and ad libitum-fed groups. These results support a role for feeding schedule and plasma corticosterone levels in food restriction-induced enhancement of the effects of methamphetamine.
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影响因子：
5.3
作者：
Borgland, SL;Malenka, RC;Bonci, A
通讯作者：
Bonci, A
影响因子：
1.9
作者：
PHILLIPS, TJ;DICKINSON, S;BURKHARTKASCH, S
通讯作者：
BURKHARTKASCH, S
影响因子：
3.4
作者：
CARROLL, ME;MEISCH, RA
通讯作者：
MEISCH, RA
DOI：
10.1093/gerona/50a.2.b78
发表时间：
1995-03-01
影响因子：
5.1
作者：
KLEBANOV, S;DIAIS, S;NELSON, JF
通讯作者：
NELSON, JF
影响因子：
3.4
作者：
Lindblom, J;Johansson, A;Schiöth, HB
通讯作者：
Schiöth, HB