Citrus Consumption and the Risk of Non-Melanoma Skin Cancer in the Women's Health Initiative.
Citrus Consumption and the Risk of Non-Melanoma Skin Cancer in the Women's Health Initiative.
复制标题
DOI：
10.3390/cancers13092173
复制
发表时间：
2021-04-30
期刊：
影响因子：
5.2
通讯作者：
Cho E
中科院分区：
文献类型：
--
作者：
Sakaki JR;Melough MM;Roberts MB;Eaton CB;Shadyab AH;Qureshi AA;Chun OK;Cho E
柑橘类产品富含呋喃香豆素，当与紫外线辐射结合时，会增加非黑色素瘤皮肤癌（NMSC）的风险。然而，很少有观察性研究评估柑橘摄入量和NMSC发病率之间的联系。本研究的目的是确定柑橘摄入量是否与妇女健康倡议观察性研究参与者的NMSC发病率有关。这项研究的结果表明，与低消费量相比，高柑橘汁消费量与NMSC事件的风险较高相关。这些发现进一步证明了某些柑橘类产品的潜在致癌性，并强调需要继续研究以确定风险因素和机制。来自动物研究的证据表明，柑橘类产品中存在的化合物呋喃香豆素与紫外线辐射结合时会增加非黑色素瘤皮肤癌（NMSC）的风险。本研究的目的是确定妇女健康倡议（WHI）观察性研究中绝经后妇女的柑橘摄入量与NMSC风险之间的关系，这些妇女在登记时年龄为50-79岁（1993-1998）。柑橘类水果、柑橘类果汁和非柑橘类水果和果汁的消费量在研究基线时使用食物频率问卷（FFQ）进行测量。NMSC病例（基底细胞癌或鳞状细胞癌）在年度随访调查期间自我报告。本分析使用的结局数据收集至2020年3月。计算了柑橘消费引起的NMSC事件的相对风险（RR）。在49,007名非西班牙裔白色参与者中，有8642例NMSC事件。以每周少于一份柑橘汁作为参考，柑橘汁摄入量引起的NMSC事件的RR和95%置信区间（CI）为1.03（0.95，1.10）一份/周，1.06（1.00，1.12）为2至4份/周，0.98（0.90，1.07）为5至6份/周，1.08（1.02，1.13）为1份或更多份/天（p趋势= 0.007）。亚组分析没有发现有意义的关联，阳光照射变量。总之，有迹象表明柑橘汁消费者中NMSC事件的风险略高;然而，需要进一步的纵向和机制研究来确认关键风险因素。
Citrus products are rich in furocoumarins, which can increase the risk of incident non-melanoma skin cancer (NMSC) when combined with ultraviolet radiation. However, few observational studies have evaluated the link between citrus intake and NMSC incidence. The aim of this study was to determine whether citrus intake was related to the NMSC incidence in participants of the Women’s Health Initiative Observational Study. The results of this study indicated that high citrus juice consumption was associated with a higher risk of incident NMSC compared to low consumption. These findings add further evidence of the potentially carcinogenic nature of certain citrus products and highlight the need to continue investigations in identifying risk factors and mechanisms. Evidence from animal studies suggests that furocoumarins, compounds present in citrus products, can increase the risk of non-melanoma skin cancer (NMSC) when combined with ultraviolet radiation. The objective of this study was to determine the relationship between citrus intake and NMSC risk among postmenopausal women from the Women’s Health Initiative (WHI) Observational Study, who were aged 50–79 years at enrollment (1993–1998). The consumption of citrus fruit, citrus juice, and non-citrus fruit and juice were measured at the baseline of the study using a food frequency questionnaire (FFQ). NMSC cases (basal or squamous cell carcinomas) were self-reported during annual follow-up surveys. The outcome data used for this analysis were collected through March 2020. The relative risk (RR) for incident NMSC by citrus consumption was calculated. Among 49,007 non-Hispanic white participants, there were 8642 cases of incident NMSC. Using less than one serving of citrus juice per week as reference, the RRs and 95% confidence intervals (CI) for incident NMSC by citrus juice intake were 1.03 (0.95, 1.10) for one serving/week, 1.06 (1.00, 1.12) for two to four servings/week, 0.98 (0.90, 1.07) for five to six servings/week, and 1.08 (1.02, 1.13) for one or more serving/day (p-trend = 0.007). Subgroup analyses did not reveal meaningful associations by sun exposure variables. In conclusion, there were indications of a slightly higher risk of incident NMSC among citrus juice consumers; however, further longitudinal and mechanistic studies are needed to confirm the key risk factors.
登录
查看更多内容
DOI：
10.1016/s0190-9622(08)81509-5
发表时间：
1994-05-01
影响因子：
13.8
作者：
MILLER, DL;WEINSTOCK, MA
通讯作者：
WEINSTOCK, MA
影响因子：
6.1
作者：
Melough, Melissa M.;Lee, Sang Gil;Chun, Ock K.
通讯作者：
Chun, Ock K.
影响因子：
6.5
作者：
GRIFFIN, AC;HAKIM, RE;KNOX, J
通讯作者：
KNOX, J
DOI：
10.1080/09637486.2016.1207157
发表时间：
2016-01-01
影响因子：
3.9
作者：
Lee, Sang Gil;Kim, Kijoon;Chun, Ock K.
通讯作者：
Chun, Ock K.
影响因子：
5.6
作者：
Anderson, GL;Manson, J;Prentice, RL
通讯作者：
Prentice, RL