Decreased anti-parietal cell antibody titer in the advanced phase of autoimmune gastritis
Decreased anti-parietal cell antibody titer in the advanced phase of autoimmune gastritis
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自身免疫性胃炎晚期抗壁细胞抗体滴度下降
DOI：
10.1080/00365521.2021.1994642
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发表时间：
2021
影响因子：
1.9
通讯作者：
Toyoshima Osamu
中科院分区：
文献类型：
--
作者：
Nishizawa Toshihiro;Watanabe Hidenobu;Yoshida Shuntaro;Toyoshima Akira;Kataoka Yosuke;Kanazawa Takamitsu;Yoshizawa Naoto;Ebinuma Hirotoshi;Suzuki Hidekazu;Toyoshima Osamu
研究背景自身免疫性胃炎（autoimmune gastritis，AIG）根据胃泌酸粘膜萎缩的严重程度，在组织学上分为早期、盛期和末期。本研究旨在阐明AIG阶段和抗壁细胞抗体title.MethodsPatients谁接受上消化道内镜检查之间的关系进行了回顾性分析。我们招募了组织学诊断为AIG并进行抗壁细胞抗体（APCA）血清学检测的患者。将AIG患者分为三组：早期组、花红组和终末期组。比较三组患者的临床特征，包括APCA滴度。结果共入组44例AIG患者。有2例患者处于早期阶段，11例处于繁荣阶段，31例处于末期阶段。APCA阳性率早期为100%，盛期为90.9%，终末期为90.3%。APCA平均滴度在早期为480 U，在盛期为220 U，在末期为150 U。从早期到末期，APCA滴度呈阶梯式下降。终末期的平均APCA滴度显著低于早期或旺盛期。此外，有一个逐步下降，血清胃泌素水平从早期阶段到结束phase.ConclusionAIG进展从早期阶段到结束phase，APCA滴度显示下降。APCA可出现负性，尤其是在终末期。
BackgroundAutoimmune gastritis (AIG) is histologically classified into three phases according to the severity of oxyntic mucosal atrophy: early, florid, and end phases. This study aimed to clarify the relationship between the AIG phase and the anti-parietal cell antibody titer.MethodsPatients who underwent upper gastrointestinal endoscopy were retrospectively reviewed in this study. We enrolled patients who were histologically diagnosed with AIG and serologically tested for anti-parietal cell antibody (APCA). AIG patients were classified into three groups: early, florid, and end phase groups. Clinical characteristics, including APCA titers, were compared among these three groups.ResultsA total of 44 AIG patients were enrolled. There were two patients in the early phase, 11 in the florid phase, and 31 in the end phase. APCA-positive rates were 100% in the early phase, 90.9% in the florid phase, and 90.3% in the end phase. The mean APCA titer was 480 U in the early phase, 220 U in the florid phase, and 150 U in the end phase. There was a stepwise decrease in the APCA titer from the early phase to the end phase. The mean APCA titer for the end phase was significantly lower than that of the early phase or florid phase. Additionally, there was a stepwise decrease in serum gastrin levels from the early phase to the end phase.ConclusionAIG progresses from the early phase to the end phase, and the APCA titer shows a decrease. The negativity of APCA could occur, especially in the end phase.
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悉尼系统：自身免疫性胃炎
影响因子：
4.1
作者：
R. Strickland
通讯作者：
R. Strickland
影响因子：
4.3
作者：
Nishizawa T;Sakitani K;Suzuki H;Yoshida S;Kataoka Y;Nakai Y;Ebinuma H;Kanai T;Toyoshima O;Koike K
通讯作者：
Koike K
影响因子：
4.5
作者：
Conti, Laura;Lenti, Marco Vincenzo;Lahner, Edith
通讯作者：
Lahner, Edith
影响因子：
1.2
作者：
Notsu, Takumi;Adachi, Kyoichi;Kinoshita, Yoshikazu
通讯作者：
Kinoshita, Yoshikazu
影响因子：
2.4
作者：
Massironi S;Cavalcoli F;Zilli A;Del Gobbo A;Ciafardini C;Bernasconi S;Felicetta I;Conte D;Peracchi M
通讯作者：
Peracchi M