Polygenic scores for schizophrenia and general cognitive ability: associations with six cognitive domains, premorbid intelligence, and cognitive composite score in individuals with a psychotic disorder and in healthy controls.
Polygenic scores for schizophrenia and general cognitive ability: associations with six cognitive domains, premorbid intelligence, and cognitive composite score in individuals with a psychotic disorder and in healthy controls.
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DOI：
10.1038/s41398-020-01094-9
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发表时间：
2020-11-30
影响因子：
6.8
通讯作者：
Melle I
中科院分区：
文献类型：
--
作者：
Engen MJ;Lyngstad SH;Ueland T;Simonsen CE;Vaskinn A;Smeland O;Bettella F;Lagerberg TV;Djurovic S;Andreassen OA;Melle I
认知障碍被认为是精神分裂症和其他精神病的核心特征。健康的一级亲属也有较小程度的认知障碍。尽管最近的研究表明精神分裂症与一般认知能力之间存在（负）遗传相关性，但精神分裂症的多基因风险与个体认知表型之间的关联仍不清楚。我们在这里研究了精神分裂症多基因评分 (SCZPGS) 与 6 个明确的认知领域之间的关联，此外还对 731 名精神障碍参与者和 851 名健康对照者进行了认知能力的综合测量和病前智力能力的测量。我们还研究了一般认知能力 PGS (COGPGS) 与同一样本中相同认知领域之间的关联。我们发现，无论是精神障碍患者还是健康对照者，SCZPGS 与任何认知表型之间都没有显着关联。对于 COGPGS，我们观察到健康对照者与认知表型的关联性强于精神障碍参与者。在健康对照中，COGPGS（p 值阈值≥0.01）和工作记忆之间的关联在 Bonferroni 校正后仍然显着（β = 0.12，p = 8.6 × 10−5）。总而言之，SCZPGS 和 COGPGS 与精神障碍参与者的认知表现之间缺乏关联，这表明环境因素或未经评估的遗传因素在精神障碍认知障碍的发展中发挥了作用。工作记忆作为一种重要的认知表型值得进一步研究。
Cognitive impairments are considered core features in schizophrenia and other psychotic disorders. Cognitive impairments are, to a lesser degree, also documented in healthy first-degree relatives. Although recent studies have shown (negative) genetic correlations between schizophrenia and general cognitive ability, the association between polygenic risk for schizophrenia and individual cognitive phenotypes remains unclear. We here investigated the association between a polygenic score for schizophrenia (SCZPGS) and six well-defined cognitive domains, in addition to a composite measure of cognitive ability and a measure of premorbid intellectual ability in 731 participants with a psychotic disorder and 851 healthy controls. We also investigated the association between a PGS for general cognitive ability (COGPGS) and the same cognitive domains in the same sample. We found no significant associations between the SCZPGS and any cognitive phenotypes, in either patients with a psychotic disorder or healthy controls. For COGPGS we observed stronger associations with cognitive phenotypes in healthy controls than in participants with psychotic disorders. In healthy controls, the association between COGPGS (at the p value threshold of ≥0.01) and working memory remained significant after Bonferroni correction (β = 0.12, p = 8.6 × 10−5). Altogether, the lack of associations between SCZPGS and COGPGS with cognitive performance in participants with psychotic disorders suggests that either environmental factors or unassessed genetic factors play a role in the development of cognitive impairments in psychotic disorders. Working memory should be further studied as an important cognitive phenotype.
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影响因子：
16.6
作者：
Bansal V;Mitjans M;Burik CAP;Linnér RK;Okbay A;Rietveld CA;Begemann M;Bonn S;Ripke S;de Vlaming R;Nivard MG;Ehrenreich H;Koellinger PD
通讯作者：
Koellinger PD
影响因子：
11
作者：
Davies G;Marioni RE;Liewald DC;Hill WD;Hagenaars SP;Harris SE;Ritchie SJ;Luciano M;Fawns-Ritchie C;Lyall D;Cullen B;Cox SR;Hayward C;Porteous DJ;Evans J;McIntosh AM;Gallacher J;Craddock N;Pell JP;Smith DJ;Gale CR;Deary IJ
通讯作者：
Deary IJ
影响因子：
--
作者：
Glahn, David C.;Almasy, Laura;Barguil, Marcela;Hare, Elizabeth;Peralta, Juan Manuel;Kent, Jack W., Jr.;Dassori, Albana;Contreras, Javier;Pacheco, Adriana;Lanzagorta, Nuria;Nicolini, Humberto;Raventos, Henriette;Escamilla, Michael A.
通讯作者：
Escamilla, Michael A.
影响因子：
30.8
作者：
Das, Sayantan;Forer, Lukas;Schoenherr, Sebastian;Sidore, Carlo;Locke, Adam E.;Kwong, Alan;Vrieze, Scott I.;Chew, Emily Y.;Levy, Shawn;McGue, Matt;Schlessinger, David;Stambolian, Dwight;Loh, Po-Ru;Iacono, William G.;Swaroop, Anand;Scott, Laura J.;Cucca, Francesco;Kronenberg, Florian;Boehnke, Michael;Abecasis, Goncalo R.;Fuchsberger, Christian
通讯作者：
Fuchsberger, Christian
影响因子：
5.3
作者：
Green, Michael F.
通讯作者：
Green, Michael F.