Paraneoplastic neuromyelitis optica spectrum disorder associated with malignant melanoma: A case report.

Paraneoplastic neuromyelitis optica spectrum disorder associated with malignant melanoma: A case report.
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DOI:
10.1111/1759-7714.13965
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发表时间:
2021-06
期刊:
影响因子:
2.9
通讯作者:
Yatera K
Yatera K
中科院分区:
医学3区
文献类型:
--
作者:
Morimoto T;Hayashida S;Yamasaki K;Sasahara Y;Takaki T;Yatera K

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视神经脊髓炎谱系疾病(NMOSD)是一种累及中枢神经系统、影响脊髓和视神经的自身免疫性脱髓鞘疾病。与恶性黑色素瘤相关的副肿瘤NMOSD的报道很少。在这里,我们报告一例罕见的抗水通道蛋白4(AQP4)抗体阳性的NMOSD与恶性黑色素瘤相关。一名61岁的日本妇女在被诊断为抗AQP4抗体阳性的NMOSD四年后被诊断为恶性黑色素瘤和肺转移。在诊断和治疗NMOSD患者时,医生应该意识到至少几年的恶性肿瘤发展。这只是第二例报道的抗AQP4抗体阳性的NMOSD合并恶性黑色素瘤。内科医生应该在诊断和治疗NMOSD患者后至少几年内意识到恶性肿瘤的发展。
Neuromyelitis optica spectrum disorders (NMOSDs) are autoimmune demyelinating diseases involving the central nervous system, affecting the spinal cord and optic nerves. There are few reports of paraneoplastic NMOSD associated with malignant melanoma. Here, we report a rare case of anti‐aquaporin 4 (AQP4) antibody‐positive NMOSD associated with malignant melanoma. A 61‐year‐old Japanese woman was diagnosed with malignant melanoma and lung metastasis four years after a diagnosis of anti‐AQP4 antibody‐positive NMOSD. When diagnosing and treating patients with NMOSD, physicians should be aware of the development of malignancy for at least several years. This is only the second reported case of anti‐AQP4 antibody‐positive NMOSD with malignant melanoma. Physicians should be aware of development of malignancy for at least several years after diagnosing and treating patients with NMOSD.
DOI: 10.1212/nxi.0000000000000482
发表时间: 2018-09
期刊: Neurology(R) neuroimmunology & neuroinflammation
影响因子: --
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