Incidence, Risk Factors and Consequences of Epilepsy-Related Injuries and Accidents: A Retrospective, Single Center Study.
Incidence, Risk Factors and Consequences of Epilepsy-Related Injuries and Accidents: A Retrospective, Single Center Study.
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DOI：
10.3389/fneur.2018.00414
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发表时间：
2018
影响因子：
3.4
通讯作者：
Strzelczyk A
中科院分区：
文献类型：
--
作者：
Willems LM;Watermann N;Richter S;Kay L;Hermsen AM;Knake S;Rosenow F;Strzelczyk A
简介：本研究旨在评估德国癫痫中心门诊部癫痫相关伤害和事故（ERIA）的风险因素和发生率，该中心为超过100万居民的城乡混合人群提供医疗保健。研究方法：在2013年10月至2014年9月期间，使用经验证的患者问卷进行了数据采集，该问卷涉及社会经济状况、癫痫病程、生活质量（QoL）、抑郁、与癫痫发作或不适当的发作期行为模式相关的损伤和事故，为期3个月。进行单因素分析、多元检验和回归分析，以确定与ERIA相关的可能变量。结果：共入组并分析了292例患者（平均年龄40.8岁，范围18-86岁; 55%为女性）。75%的患者被诊断为局灶性癫痫。大多数患者接受抗癫痫药物（AED）综合治疗（平均AED数量：1.65）。总体而言，41例患者（14.0%）在3个月内发生癫痫相关损伤和事故。除撕裂伤（n = 18，6.2%）、擦伤和瘀伤（n = 9，3.1%）、骨折（n = 6，2.2%）和烧伤（n = 3，1.0%）外，还报告了17例轻度损伤（5.8%）。在20例（占总队列的6.8%）病例中，需要紧急医疗和住院治疗。癫痫相关损伤和事故与活动性癫痫、全身强直阵挛发作（GTCS）的发生和药物难治性病程以及病史中报告的发作性福尔斯、发作性意识丧失和发作期行为异常有关。此外，ERIA患者的抑郁发生率显著较高，生活质量较低。结论：应重视ERIA及其后果，并在每次门诊就诊时进行ERIA的标准化评估。
Introduction: This study was designed to evaluate risk factors and incidence of epilepsy-related injuries and accidents (ERIA) at an outpatient clinic of a German epilepsy center providing healthcare to a mixed urban and rural population of over one million inhabitants. Methods: Data acquisition was performed between 10/2013 and 09/2014 using a validated patient questionnaire on socioeconomic status, course of epilepsy, quality of life (QoL), depression, injuries and accidents associated with seizures or inadequate periictal patterns of behavior concerning a period of 3 months. Univariate analysis, multiple testing and regression analysis were performed to identify possible variables associated with ERIA. Results: A total of 292 patients (mean age 40.8 years, range 18–86; 55% female) were enrolled and analyzed. Focal epilepsy was diagnosed in 75% of the patients. The majority was on an antiepileptic drug (AEDs) polytherapy (mean number of AEDs: 1.65). Overall, 41 patients (14.0%) suffered from epilepsy-related injuries and accidents in a 3-month period. Besides lacerations (n = 18, 6.2%), abrasions and bruises (n = 9, 3.1%), fractures (n = 6, 2.2%) and burns (n = 3, 1.0%), 17 mild injuries (5.8%) were reported. In 20 (6.8% of the total cohort) cases, urgent medical treatment with hospitalization was necessary. Epilepsy-related injuries and accidents were related to active epilepsy, occurrence of generalized tonic-clonic seizures (GTCS) and drug-refractory course as well as reported ictal falls, ictal loss of consciousness and abnormal peri-ictal behavior in the medical history. In addition, patients with ERIA had significantly higher depression rates and lower QoL. Conclusion: ERIA and their consequences should be given more attention and standardized assessment for ERIA should be performed in every outpatient visit.
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DOI：
10.1016/j.yebeh.2016.11.015
发表时间：
2017-03
期刊：
Epilepsy & behavior : E&B
影响因子：
--
作者：
Helmers SL;Kobau R;Sajatovic M;Jobst BC;Privitera M;Devinsky O;Labiner D;Escoffery C;Begley CE;Shegog R;Pandey D;Fraser RT;Johnson EK;Thompson NJ;Horvath KJ;Centers for Disease Control and Prevention Managing Epilepsy Well Network
通讯作者：
Centers for Disease Control and Prevention Managing Epilepsy Well Network
影响因子：
5.6
作者：
Beghi, E;Cornaggia, C
通讯作者：
Cornaggia, C
影响因子：
5.1
作者：
Forsgren, I;Beghi, E;Ekman, M
通讯作者：
Ekman, M
影响因子：
2.6
作者：
Jehi, Lara;Tesar, George;Najm, Imad
通讯作者：
Najm, Imad
影响因子：
5.6
作者：
Buck, D;Baker, GA;Chadwick, DW
通讯作者：
Chadwick, DW