Short-echo, single-shot, full-intensity proton magnetic resonance spectroscopy for neurochemical profiling at 4 T: validation in the cerebellum and brainstem.
Short-echo, single-shot, full-intensity proton magnetic resonance spectroscopy for neurochemical profiling at 4 T: validation in the cerebellum and brainstem.
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DOI：
10.1002/mrm.22708
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发表时间：
2011-04
影响因子：
3.3
通讯作者：
Tkac, Ivan
中科院分区：
文献类型：
--
作者：
Oez, Guelin;Tkac, Ivan
设计并优化了一种短回波时间（TE = 24 ms）的半绝热激光序列，用于4 T下的全强度~ 1H MRS。该序列与VAPOR水抑制和三维外体积抑制（OVS）相结合，以改善定位和抑制不必要的相干性。从人脑中获得无伪影单次激发光谱，其光谱图案几乎与使用超短回波（TE = 5 ms）STEAM序列获得的光谱图案相同，这是由于半激光中的绝热重聚焦脉冲序列减少了表观TE。相对于STEAM，在幻影和人脑中显示出大约两倍高的信号强度。为了测试该序列在具有体积线圈的临床相关脑区域中的性能，从23名健康受试者的三个小脑和脑干感兴趣体积（VOI）获取半激光光谱。从相同的VOI中获取超短回波STEAM光谱，以比较半激光和STEAM获得的神经化学谱。通过这两种技术获得的小脑和脑干的神经化学特征几乎相同，验证了在相对于STEAM的较长TE下使用半激光获得的代谢物浓度的准确性。通过这两种MRS技术获得的代谢物浓度之间的高度相关性表明检测代谢物水平的受试者间变化的灵敏度。
A short echo-time (TE = 24ms) semi-adiabatic LASER sequence was designed and optimized for full intensity 1H MRS at 4T. The sequence was combined with VAPOR water suppression and three dimensional outer-volume-suppression (OVS) for improved localization and suppression of unwanted coherences. Artifact-free, single-shot spectra were obtained from the human brain with a spectral pattern almost identical to that obtained with an ultra-short echo (TE = 5ms) STEAM sequence as a result of the train of adiabatic refocusing pulses in semi-LASER that reduce the apparent TE. Approximately twofold higher signal intensity relative to STEAM was demonstrated in phantoms and the human brain. To test the performance of the sequence in clinically relevant brain regions with a volume coil, semi-LASER spectra were acquired from three cerebellar and brainstem volumes-of-interest (VOI) in 23 healthy subjects. Ultra-short echo STEAM spectra were acquired from the same VOI to compare neurochemical profiles obtained with semi-LASER to those obtained with STEAM. Neurochemical profiles of the cerebellum and brainstem acquired by these two techniques were nearly identical, validating the accuracy of the metabolite concentrations obtained with semi-LASER at the longer TE relative to STEAM. A high correlation between metabolite concentrations obtained by these two MRS techniques indicated the sensitivity to detect inter-subject variation in metabolite levels.
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影响因子：
2.2
作者：
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通讯作者：
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影响因子：
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