Predicting Successful Generation and Inhibition of Seizure-like Afterdischarges and Mapping Their Seizure Networks Using fMRI.
Predicting Successful Generation and Inhibition of Seizure-like Afterdischarges and Mapping Their Seizure Networks Using fMRI.
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DOI：
10.1016/j.celrep.2020.01.095
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发表时间：
2020-02-25
期刊：
影响因子：
8.8
通讯作者：
Lee JH
中科院分区：
文献类型：
--
作者：
Duffy BA;Choy M;Lee JH
To understand the conditions necessary to initiate and terminate seizures, optogenetically induced hippocampal seizures were investigated with LFP, fMRI, and optogenetic inhibition. During afterdischarge (AD) induction using optogenetics, simultaneous LFP recordings identified that the stimulations with earlier ictal onset times were more likely to result in ADs and were more difficult to curtail with optogenetic inhibition. These results were generalizable across two different initiation sites, the dorsal and ventral hippocampus. fMRI during optogenetic induction of AD showed that ADs initiated from the dorsal or ventral hippocampus exhibited distinct brain-wide seizure networks. Short duration seizures initiated in the dorsal and ventral hippocampus were unilateral and bilateral respectively, while longer duration seizures from either site recruited broader, bilateral networks. Interestingly, when optogenetic inhibition is ineffective at stopping seizures, the network activity spreads more extensively but largely overlaps with the network activity associated with seizures that can be stopped. These results provide novel insights on how seizures can be generated and inhibited, which has significant implications for optimizing seizure interventions.
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