Numerical simulation of flow for viscoelastic neutrophil models in a rectangular capillary network: effects of capillary shape and cell stiffness on transit time.
Numerical simulation of flow for viscoelastic neutrophil models in a rectangular capillary network: effects of capillary shape and cell stiffness on transit time.
复制标题
矩形毛细血管网络中粘弹性中性粒细胞模型流动的数值模拟：毛细血管形状和细胞刚度对通过时间的影响。
DOI：
10.3233/thc-2007-15207
复制
发表时间：
2007
期刊：
影响因子：
--
通讯作者：
T. Hayase
中科院分区：
文献类型：
--
作者：
A. Shirai;R. Fujita;T. Hayase
肺微血管中的中性粒细胞浓度高于全身大血管中的中性粒细胞浓度。人们认为高浓度的中性粒细胞有利于它们有效地募集到炎症部位。因此，为了了解中性粒细胞在免疫系统中的作用，阐明它们在肺微血管中的流动特征非常重要。在之前的研究中，我们开发了一个模型来模拟毛细血管网络中中性粒细胞的流动，其中细胞被建模为具有皮质张力的麦克斯韦材料的球体，毛细管段被建模为直管中的弧形收缩。在本文中，研究了简化的肺泡毛细血管网络模型中的中性粒细胞的流动，以了解各种收缩形状和细胞刚度。最后，结果表明，细胞通过时间的变异系数（即标准差除以平均通过时间）和平均通过时间随着毛细管段变陡或变紧或当细胞变硬而增加。通过时间的平均值超过了真实肺部中发生的所有情况的中位数，尽管它们之间的差异很小。
The concentration of neutrophils in the pulmonary microvasculature is higher than in large systemic vessels. It is thought that the high concentration of neutrophils facilitates their effective recruitment to sites of inflammation. Thus, in order to understand the role of neutrophils in the immune system, it is important to clarify their flow characteristics in the pulmonary microvasculature. In a previous study, we developed a model to simulate the flow of neutrophils in a capillary network, in which the cells were modeled as spheres of a Maxwell material with a cortical tension and the capillary segments were modeled as arc-shaped constrictions in straight pipes. In the present paper, the flow of neutrophils in a simplified alveolar capillary network model is investigated for various constriction shapes and cell stiffnesses. Finally, it is shown that both the coefficient of variation of the transit time of the cells, which is the standard deviation divided by the mean transit time, and the mean transit time increase as the capillary segments become steep or tight, or when the cells become hard. The mean value of the transit time exceeds the median for all of the conditions that occur in real lungs, although the difference between them is small.
登录
查看更多内容
影响因子：
3.4
作者：
YEUNG, A;EVANS, E
通讯作者：
EVANS, E
影响因子：
3.3
作者：
Huang, YQ;Doerschuk, CM;Kamm, RD
通讯作者：
Kamm, RD
DOI：
10.1115/1.2895716
发表时间：
1994
期刊：
Journal of biomechanical engineering
影响因子：
--
作者：
Tran-Son-Tay,R;Kirk3rd,TF;Zhelev,DV;Hochmuth,RM
通讯作者：
Hochmuth,RM
影响因子：
3.4
作者：
Bathe, M;Shirai, A;Kamm, RD
通讯作者：
Kamm, RD
白细胞的被动变形和主动运动。
DOI：
10.1115/1.2891187
发表时间：
1990
期刊：
Journal of biomechanical engineering
影响因子：
--
作者：
Skalak,R;Dong,C;Zhu,C
通讯作者：
Zhu,C