Brain-derived neurotrophic factor functions as a metabotrophin to mediate the effects of exercise on cognition.
Brain-derived neurotrophic factor functions as a metabotrophin to mediate the effects of exercise on cognition.
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DOI：
10.1111/j.1460-9568.2008.06524.x
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发表时间：
2008-12
期刊：
影响因子：
--
通讯作者：
Ying Z
中科院分区：
文献类型：
--
作者：
Gomez-Pinilla F;Vaynman S;Ying Z
脑源性神经营养因子（BDNF）已被证明介导运动对突触可塑性和认知功能的影响，在这一过程中，能量代谢可能起着重要作用。本研究的目的是研究运动对大鼠海马参与调节能量管理和认知功能的分子表达的影响，并确定BDNF在这些事件中的作用。一周的自愿运动，增强学习和记忆能力，提高了参与能量代谢的分子系统[AMP活化蛋白激酶（AMPK），普遍存在的线粒体肌酸激酶（uMtCK）和解偶联蛋白2]以及在能量和突触可塑性界面工作的分子[BDNF，胰岛素样生长因子I（IGF-I）和ghrelin]的表达。BDNF mRNA水平与AMPK、uMtCK、IGF-I和ghrelin mRNA水平相关。抑制运动期间脑源性神经营养因子的作用会消除运动介导的空间学习增强，并增加所研究的所有分子系统的表达。BDNF阻断也破坏了学习速度与AMPK、uMtCK、ghrelin和IGF-I mRNA水平之间的关联。这些发现表明，运动对突触可塑性和认知功能的影响涉及能量代谢的元素，BDNF似乎作为代谢营养因子在这两个过程之间的界面上起作用。
Brain-derived neurotrophic factor (BDNF) has been shown to mediate the effects of exercise on synaptic plasticity and cognitive function, in a process in which energy metabolism probably plays an important role. The purpose of the present study was to examine the influence of exercise on rat hippocampal expression of molecules involved in the regulation of energy management and cognitive function, and to determine the role of BDNF in these events. One week of voluntary exercise that enhanced learning and memory performance elevated the expression of molecular systems involved in the metabolism of energy [AMP-activated protein kinase (AMPK), ubiquitous mitochondrial creatine kinase (uMtCK) and uncoupling protein 2] and molecules that work at the interface of energy and synaptic plasticity [BDNF, insulin-like growth factor I (IGF-I) and ghrelin]. The levels of BDNF mRNA were associated with the mRNA levels of AMPK, uMtCK, IGF-I and ghrelin. Inhibiting the action of BDNF during exercise abolished an exercise-mediated enhancement in spatial learning and increased the expression of all of the molecular systems studied. BDNF blocking also disrupted the association between learning speed and levels of AMPK, uMtCK, ghrelin and IGF-I mRNAs. These findings suggest that the effects of exercise on synaptic plasticity and cognitive function involve elements of energy metabolism, and that BDNF seems to work at the interface between the two processes as a metabotrophin.
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影响因子：
16.2
作者：
Cowley, MA;Smith, RG;Horvath, TL
通讯作者：
Horvath, TL
DOI：
10.1016/s0006-291x(02)02740-7
发表时间：
2002-12-20
影响因子：
3.1
作者：
Carlini, VP;Monzón, ME;de Barioglio, SR
通讯作者：
de Barioglio, SR
影响因子：
4.3
作者：
Boero, J;Qin, W;Khuchua, Z
通讯作者：
Khuchua, Z
DOI：
10.1016/s0169-328x(97)00071-5
发表时间：
1997-08-01
期刊：
MOLECULAR BRAIN RESEARCH
影响因子：
--
作者：
Guan, XM;Yu, H;Howard, AD
通讯作者：
Howard, AD
影响因子：
3.3
作者：
Griesbach, GS;Hovda, DA;Gomez-Pinilla, F
通讯作者：
Gomez-Pinilla, F