Recalling happy memories in remitted depression: a neuroimaging investigation of the repair of sad mood.
Recalling happy memories in remitted depression: a neuroimaging investigation of the repair of sad mood.
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DOI：
10.3758/s13415-013-0216-0
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发表时间：
2014-06
期刊：
影响因子：
--
通讯作者：
Gotlib IH
中科院分区：
文献类型：
--
作者：
Foland-Ross LC;Cooney RE;Joormann J;Henry ML;Gotlib IH
重度抑郁症（MDD）是一种复发性情绪障碍。重度抑郁症的高复发率表明存在稳定的易感因素，这些因素使有重度抑郁症病史的个体再次发作的风险增加。先前的研究已经将缓解状态与难以使用愉快的自传式记忆来修复悲伤情绪联系起来，从而增加了抑郁复发的脆弱性。在本研究中，我们研究了这些困难的神经关联。在悲伤情绪诱导和通过回忆情绪不一致的积极自传体记忆从悲伤情绪状态中恢复的过程中，对16名目前情绪良好、抑郁缓解的个体和16名健康（对照组）女性进行了功能磁共振成像（fMRI）。电影片段诱发了参与者的悲伤情绪；然后参与者回忆积极的自传式记忆，这一过程之前被证明可以修复负面影响。在悲伤情绪诱导和自动情绪调节过程中，对照组参与者的左腹外侧前额叶皮层（vlPFC）和楔叶皮层均表现出激活；相比之下，这些区域的激活程度有所下降。此外，探索性分析显示，在20个月的随访评估中，情绪调节过程中激活水平的降低预示着抑郁症状的恶化。这些发现强调了vlPFC和楔叶在情绪状态的体验和调节中的动态作用，并表明这些大脑区域的功能异常与抑郁症的历史和易患性有关。
Major depressive disorder (MDD) is a recurrent mood disorder. The high rate of recurrence of MDD suggests the presence of stable vulnerability factors that place individuals with a history of major depression at an increased risk for the onset of another episode. Previous research has linked the remitted state, and therefore increased vulnerability for depressive relapse, with difficulties in the use of pleasant autobiographical memories to repair sad mood. In the present study, we examined the neural correlates of these difficulties. Groups of 16 currently euthymic, remitted depressed individuals and 16 healthy (control) women underwent functional magnetic resonance imaging (fMRI) during sad mood induction and during recovery from a sad mood state through recall of mood-incongruent positive autobiographical memories. Sad mood was induced in participants by using film clips; participants then recalled positive autobiographical memories, a procedure previously shown to repair negative affect. During both the sad mood induction and automatic mood regulation, control participants exhibited activation in the left ventrolateral prefrontal cortex (vlPFC) and cuneus; in contrast, remitted participants exhibited a decrease in activation in these regions. Furthermore, exploratory analyses revealed that reduced activation levels during mood regulation predicted a worsening of depressive symptoms at a 20-month follow-up assessment. These findings highlight a dynamic role of the vlPFC and cuneus in the experience and modulation of emotional states and suggest that functional anomalies of these brain regions are associated with a history of, and vulnerability to, depression.
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影响因子：
4.6
作者：
Joormann J;Cooney RE;Henry ML;Gotlib IH
通讯作者：
Gotlib IH