Neural correlates of automatic mood regulation in girls at high risk for depression.
Neural correlates of automatic mood regulation in girls at high risk for depression.
复制标题
抑郁症高风险女孩自动情绪调节的神经相关性。
DOI：
10.1037/a0025294
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发表时间：
2012-02
影响因子：
4.6
通讯作者：
Gotlib IH
中科院分区：
文献类型：
--
作者：
Joormann J;Cooney RE;Henry ML;Gotlib IH
抑郁母亲的女儿患抑郁症的风险显著增加。然而，我们对导致这种风险的具体因素知之甚少。有效调节负面情绪的能力对情绪和身体健康至关重要，并可能在影响抑郁风险方面发挥重要作用。我们研究了母亲在女儿有生之年经历了反复的抑郁症发作的从未紊乱的女儿与从未紊乱的母亲的女儿在负面情绪诱导和自动情绪调节期间的神经激活模式是否存在差异。通过使用电影片段，女儿的悲伤情绪被诱导出来；然后，女儿回忆起积极的自传式记忆，这是之前展示的修复负面情绪的过程。在情绪诱导期间，高风险女孩比低风险女孩在经常受到负面情绪影响的大脑区域表现出更大的激活，包括杏仁核和腹外侧额前皮质。相比之下，在自动情绪调节期间，低风险的女儿在经常与情绪自上而下调节相关的大脑区域表现出比高风险女儿更大的激活，包括背侧前额叶皮质和背侧前扣带回皮质。这些发现表明，抑郁风险高的女孩和低风险的女孩在经历和修复负面情绪时的神经激活模式都不同，并表明神经功能异常在抑郁发作之前。
Daughters of depressed mothers are at significantly elevated risk for developing a depressive disorder themselves. We have little understanding, however, of the specific factors that contribute to this risk. The ability to regulate negative affect effectively is critical to emotional and physical health and may play an important role in influencing risk for depression. We examined whether never-disordered daughters whose mothers have experienced recurrent episodes of depression during their daughters’ lifetime differ from never-disordered daughters of never-disordered mothers in their patterns of neural activation during a negative mood induction and during automatic mood regulation. Sad mood was induced in daughters through the use of film clips; daughters then recalled positive autobiographical memories, a procedure shown previously to repair negative affect. During the mood induction, high-risk girls exhibited greater activation than did low-risk daughters in brain areas that have frequently been implicated in the experience of negative affect, including the amygdala and ventrolateral prefrontal cortex. In contrast, during automatic mood regulation, low-risk daughters exhibited greater activation than did their high-risk counterparts in brain areas that have frequently been associated with top-down regulation of emotion, including the dorsolateral prefrontal cortex and dorsal anterior cingulate cortex. These findings indicate that girls at high and low risk for depression differ in their patterns of neural activation both while experiencing, and while repairing negative affect, and suggest that anomalies in neural functioning precede the onset of a depressive episode.
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影响因子：
5.7
作者：
Kalisch, Raffael;Wiech, Katja;Dolan, Raymond J.
通讯作者：
Dolan, Raymond J.
影响因子：
4.6
作者：
Joormann, J;Siemer, M
通讯作者：
Siemer, M
影响因子：
2.6
作者：
Josephson, BR;Singer, JA;Salovey, P
通讯作者：
Salovey, P
DOI：
10.1016/s0065-2407(02)80042-8
发表时间：
2002-01-01
期刊：
ADVANCES IN CHILD DEVELOPMENT AND BEHAVIOR, VOL 30
影响因子：
--
作者：
Eisenberg, N;Morris, AS
通讯作者：
Morris, AS
影响因子：
5.3
作者：
Beauregard, M;Lévesque, J;Bourgouin, P
通讯作者：
Bourgouin, P