Horizontal transfers of Tc1 elements between teleost fishes and their vertebrate parasites, lampreys.
Horizontal transfers of Tc1 elements between teleost fishes and their vertebrate parasites, lampreys.
复制标题
Tc1 元素在硬骨鱼与其脊椎动物寄生虫七鳃鳗之间的水平转移。
DOI：
10.1093/gbe/evs069
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发表时间：
2012
影响因子：
3.3
通讯作者：
Meyer A
中科院分区：
文献类型：
--
作者：
Kuraku S;Qiu H;Meyer A
基因水平转移是原核生物和单细胞真核生物进化和基因组形成的重要机制。然而，HGT被认为是非常罕见的真核生物。我们发现了大量的DNA转座子，编码转座酶的Tc 1元件，在多个硬骨鱼和七鳃鳗之间，最后共享一个共同的祖先超过500 Ma。这组Tc 1元件的成员被发现表现出马赛克系统发育分布，但它们的序列高度相似，即使在远亲谱系之间（95%-99%的同一性）。我们的分子系统发育分析表明，这种元素的水平转移反复发生，涉及多个硬骨鱼类，仅在遗传上是远亲。有趣的是，几乎所有受影响的硬骨鱼谱系也被称为是七鳃鳗寄生，这表明脊椎动物之间的水平转移可能发生通过寄生虫-宿主相互作用。几种北方七鳃鳗物种的基因组，包括海七鳃鳗（Petromyzon marinus）的基因组，被发现含有数千份外来元素。这一事件的影响进行了讨论有关其他奇特的基因组特征的七鳃鳗。
Horizontal gene transfer (HGT) has been recognized to be an important mechanism that shaped the evolution and genomes of prokaryotes and unicellular eukaryotes. However, HGT is regarded to be exceedingly rare among eukaryotes. We discovered massive transfers of a DNA transposon, a Tc1 element encoding a transposase, between multiple teleost fishes and lampreys that last shared a common ancestor over 500 Ma. Members of this group of Tc1 elements were found to exhibit a mosaic phylogenetic distribution, yet their sequences were highly similar even between distantly related lineages (95%–99% identity). Our molecular phylogenetic analyses suggested that horizontal transfers of this element happened repeatedly, involving multiple teleost fishes that are phylogenetically only distantly related. Interestingly, almost all the affected teleost lineages are also known to be subject to lamprey parasitism, suggesting that the horizontal transfers between vertebrates might have occurred through parasite–host interaction. The genomes of several northern hemisphere lamprey species, including that of the sea lamprey (Petromyzon marinus), were found to contain thousands of copies of the foreign elements. Impact of this event is discussed in relation to other peculiar genomic features of lampreys.
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影响因子：
14.9
作者：
Koonin EV
通讯作者：
Koonin EV
影响因子：
5.4
作者：
Kikugawa K;Katoh K;Kuraku S;Sakurai H;Ishida O;Iwabe N;Miyata T
通讯作者：
Miyata T
影响因子：
0.9
作者：
Kuraku, Shigehiro
通讯作者：
Kuraku, Shigehiro
Ensembl 2009。
影响因子：
14.9
作者：
Hubbard TJ;Aken BL;Ayling S;Ballester B;Beal K;Bragin E;Brent S;Chen Y;Clapham P;Clarke L;Coates G;Fairley S;Fitzgerald S;Fernandez-Banet J;Gordon L;Graf S;Haider S;Hammond M;Holland R;Howe K;Jenkinson A;Johnson N;Kahari A;Keefe D;Keenan S;Kinsella R;Kokocinski F;Kulesha E;Lawson D;Longden I;Megy K;Meidl P;Overduin B;Parker A;Pritchard B;Rios D;Schuster M;Slater G;Smedley D;Spooner W;Spudich G;Trevanion S;Vilella A;Vogel J;White S;Wilder S;Zadissa A;Birney E;Cunningham F;Curwen V;Durbin R;Fernandez-Suarez XM;Herrero J;Kasprzyk A;Proctor G;Smith J;Searle S;Flicek P
通讯作者：
Flicek P
影响因子：
14.9
作者：
Katoh K;Kuma K;Toh H;Miyata T
通讯作者：
Miyata T