Roles for transforming growth factor beta superfamily proteins in early folliculogenesis.
Roles for transforming growth factor beta superfamily proteins in early folliculogenesis.
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DOI：
10.1055/s-0028-1108006
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发表时间：
2009-01
影响因子：
2.7
通讯作者：
Mayo KE
中科院分区：
文献类型：
--
作者：
Trombly DJ;Woodruff TK;Mayo KE
原始卵泡的形成以及随后卵泡向初级和次级阶段的转变涵盖了哺乳动物卵泡发生过程中的早期事件。这些过程建立了卵巢卵泡池和准备卵泡，以进入生殖周期的后续生长阶段。卵泡形成过程中的扰动会显着影响原始卵泡池的大小，卵泡转变的改变会导致卵泡停滞在不成熟阶段或导致卵泡储备过早耗尽。确定调节原始卵泡形成和早期卵泡生长的分子事件可能会导致新的生育治疗方法的开发。在过去的十年中，通过小鼠遗传模型、体内注射研究和离体器官培养方法，已经鉴定出许多介导卵泡发生早期阶段的生长因子和信号蛋白。这些研究揭示了卵巢中蛋白质转化生长因子 β (TGF-β) 超家族的重要作用。本文回顾了 TGF-β 家族蛋白的这些作用，并特别关注我们实验室关于激活素在早期卵泡发生中的功能的工作。
Primordial follicle formation and the subsequent transition of follicles to the primary and secondary stages encompass the early events during folliculogenesis in mammals. These processes establish the ovarian follicle pool and prime follicles for entry into subsequent growth phases during the reproductive cycle. Perturbations during follicle formation can affect the size of the primordial follicle pool significantly, and alterations in follicle transition can cause follicles to arrest at immature stages or result in premature depletion of the follicle reserve. Determining the molecular events that regulate primordial follicle formation and early follicle growth may lead to the development of new fertility treatments. Over the last decade, many of the growth factors and signaling proteins that mediate the early stages of folliculogenesis have been identified using mouse genetic models, in vivo injection studies, and ex vivo organ culture approaches. These studies reveal important roles for the transforming growth factor β (TGF-β) superfamily of proteins in the ovary. This article reviews these roles for TGF-β family proteins and focuses in particular on work from our laboratories on the functions of activin in early folliculogenesis.
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