Immune Cells on the Donor Corneal Endothelium After Corneal Transplantation
Immune Cells on the Donor Corneal Endothelium After Corneal Transplantation
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角膜移植后供体角膜内皮上的免疫细胞
DOI：
10.1097/ico.0000000000001678
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发表时间：
2018
期刊：
影响因子：
2.8
通讯作者：
Kinoshita S
中科院分区：
文献类型：
--
作者：
Okumura N;Inoue R;Nakano S;Imai H;Matsumoto D;Kayukawa K;Wakimasu K;Kitazawa K;Koizumi N;Kinoshita S
目的：本研究的目的是通过接触镜面显微镜观察穿透性角膜移植术（PK）和Descemet剥离自动内皮角膜移植术（DSAEK）患者是否存在假定的免疫细胞。方法：本横断面研究对2015年1月至3月期间接受过PK或DSAEK随访的连续患者进行。疑似免疫细胞的“细胞样白点”通过扫描狭缝接触镜面显微镜进行评估。还研究了假定免疫细胞的分级与临床参数（如角膜内皮细胞密度、手术后时间和类固醇给药滴度）之间的关系。结果：54例患者共54眼接受PK（32眼/32例）和DSAEK（22眼/22例）检查，所有患者均观察到可疑免疫细胞。在PK组和DSAEK组中，推定免疫细胞等级为1、2、3和4的患者人数分别为19、10、2和1,10、8、2和2 （P= 0.663）。免疫细胞分级与临床参数之间无统计学意义的关联。结论：54例接受PK或DSAEK的患者在角膜内皮移植物上均观察到免疫细胞。虽然免疫细胞数量在患者之间存在差异，且与临床参数无相关性，但分析免疫细胞对术后角膜内皮细胞损失的影响，有利于未来开展前瞻性研究。
Purpose:The aim of this study was to investigate the existence of presumed immune cells observed by contact specular microscopy in patients who underwent penetrating keratoplasty (PK) and Descemet stripping automated endothelial keratoplasty (DSAEK).Methods:This cross-sectional study was conducted on consecutive patients who underwent follow-up visits between January and March 2015 for previously performed PK or DSAEK. Presumed immune cell–suspected “cell-like white dots” were evaluated by scanning slit contact specular microscopy. The association between the grading of presumed immune cells with clinical parameters, such as corneal endothelial cell density, time after surgery, and the titer of steroid administration, was also investigated.Results:A total of 54 eyes of 54 patients who underwent PK (32 eyes/32 patients) and DSAEK (22 eyes/22 patients) were evaluated, and suspected immune cells were observed in all patients. In the PK and DSAEK groups, the number of patients in the presumed immune cell grades 1, 2, 3, and 4 were 19, 10, 2, and 1 and 10, 8, 2, and 2, respectively (P= 0.663). No statistically significant association was found between the immune cell grades and the clinical parameters.Conclusions:Immune cells were observed on the corneal endothelial grafts in all 54 patients who underwent PK or DSAEK. Although the number of immune cells varied between patients and showed no correlation with clinical parameters, it would be beneficial to conduct a future prospective study to analyze the effect of immune cells on postoperative corneal endothelial cell loss.
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影响因子：
13.7
作者：
Ing, JJ;Ing, HH;Bourne, WM
通讯作者：
Bourne, WM
影响因子：
4.2
作者：
Ham, Lisanne;van Luijk, Chantal;Melles, Gerrit R. J.
通讯作者：
Melles, Gerrit R. J.
自体旋转角膜移植术后内皮细胞损失
DOI：
--
发表时间：
2004
期刊：
Graefe's Archive for Clinical and Experimental Ophthalmology
影响因子：
--
作者：
F. Birnbaum;T. Reinhard;D. Böhringer;R. Sundmacher
通讯作者：
R. Sundmacher
影响因子：
3.4
作者：
Patel, Sanjay V.
通讯作者：
Patel, Sanjay V.
影响因子：
4.2
作者：
BOURNE, WM;HODGE, DO;NELSON, LR
通讯作者：
NELSON, LR