Mucosal Immunosenescence in the Gastrointestinal Tract: A Mini-Review.
Mucosal Immunosenescence in the Gastrointestinal Tract: A Mini-Review.
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DOI：
10.1159/000368897
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发表时间：
2015
期刊：
影响因子：
3.5
通讯作者：
Fujihashi K
中科院分区：
文献类型：
--
作者：
Sato S;Kiyono H;Fujihashi K
已经表明病原体特异性分泌型伊加（SIgA）抗体（Ab）是粘膜表面用于宿主防御的主要参与者。然而，粘膜免疫系统的改变发生在晚期衰老中，这导致不能诱导SIgA抗体以保护免受感染性疾病。粘膜衰老的迹象首先出现在肠道免疫系统中。此外，肠道微生物群的变化最有可能影响粘膜免疫。为了克服粘膜免疫的免疫老化下降，包括粘膜树突状细胞（DC）靶向的几种佐剂系统已被证明是有吸引力的和有效的免疫策略。类似地，抗原（Ag）摄取-M细胞是促进Ag特异性粘膜免疫应答的理想靶标。然而，M细胞的数量在老年小鼠中减少。在这方面，Spi-B，M细胞的功能和结构分化的必要转录因子，可能是一个有效的策略，诱导有效的粘膜免疫老化。
It has been shown that pathogen-specific secretory IgA (SIgA) antibody (Ab) is the major player at mucosal surfaces for host defense. However, alterations in the mucosal immune system occur in advanced aging which results in a failure of induction of SIgA Abs for protection from infectious diseases. Signs of mucosal senescence first appear in the gut immune system. Further, changes in the intestinal microbiota most likely influence mucosal immunity. To overcome the immunological aging decline in mucosal immunity, several adjuvant systems including mucosal dendritic cell (DC) targeting have been shown to be attractive and effective immunological strategies. Similarly, antigen (Ag) uptake-M cells are ideal targets for facilitating Ag-specific mucosal immune responses. However, the numbers of M cells are reduced in aged mice. In this regard, Spi-B, an essential transcription factor for the functional and structural differentiation of M cells could be a potent strategy for the induction of effective mucosal immunity in aging.
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影响因子：
3.7
作者：
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影响因子：
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影响因子：
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影响因子：
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作者：
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通讯作者：
Mabbott, N. A.