The functional maturation of M cells is dramatically reduced in the Peyer's patches of aged mice.
The functional maturation of M cells is dramatically reduced in the Peyer's patches of aged mice.
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DOI：
10.1038/mi.2012.141
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发表时间：
2013-09
影响因子：
8
通讯作者：
Mabbott, N. A.
中科院分区：
文献类型：
--
作者：
Kobayashi, A.;Donaldson, D. S.;Erridge, C.;Kanaya, T.;Williams, I. R.;Ohno, H.;Mahajan, A.;Mabbott, N. A.
微褶细胞（M细胞）跨派尔集合淋巴结滤泡相关上皮（FAE）的抗原转胞吞对于诱导针对粘膜抗原的有效免疫应答是重要的。粘膜免疫反应受到老化的影响，但对M细胞的影响尚不清楚。我们发现，老年小鼠FAE中的M细胞密度显着降低。因此，老年派伊尔集合淋巴结在其跨FAE转胞吞颗粒内腔抗原的能力方面明显不足。衰老特异性地损害了Spi-B的表达和M细胞的下游功能成熟。衰老也显著损害了FAE的C-C基序趋化因子配体20表达。因此，更少的B细胞被吸引到FAE，潜在地降低了它们促进M细胞成熟的能力。我们的研究表明，老化显着阻碍了M细胞的功能成熟，揭示了一个重要的老化相关的缺陷，粘膜免疫系统的采样内腔抗原的能力。
The transcytosis of antigens across the follicle-associated epithelium (FAE) of Peyer's patches by microfold cells (M cells) is important for the induction of efficient immune responses to mucosal antigens. The mucosal immune response is compromised by ageing, but effects on M cells were unknown. We show that M-cell density in the FAE of aged mice was dramatically reduced. As a consequence, aged Peyer's patches were significantly deficient in their ability to transcytose particulate lumenal antigen across the FAE. Ageing specifically impaired the expression of Spi-B and the downstream functional maturation of M cells. Ageing also dramatically impaired C-C motif chemokine ligand 20 expression by the FAE. As a consequence, fewer B cells were attracted towards the FAE, potentially reducing their ability to promote M-cell maturation. Our study demonstrates that ageing dramatically impedes the functional maturation of M cells, revealing an important ageing-related defect in the mucosal immune system's ability to sample lumenal antigens.
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影响因子：
2.2
作者：
Inman, CF;Rees, LEN;Bailey, M
通讯作者：
Bailey, M
鼠伤寒沙门氏菌通过穿透和破坏佩耶斑块的专门上皮细胞来引起鼠的感染。
影响因子：
15.3
作者：
Jones, Bradley D.;Ghori, Nafisa;Falkow, Stanley
通讯作者：
Falkow, Stanley
DOI：
10.1084/jem.20070607
发表时间：
2007-11-26
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Nochi T;Yuki Y;Matsumura A;Mejima M;Terahara K;Kim DY;Fukuyama S;Iwatsuki-Horimoto K;Kawaoka Y;Kohda T;Kozaki S;Igarashi O;Kiyono H
通讯作者：
Kiyono H
影响因子：
3
作者：
Ren Z;Gay R;Thomas A;Pae M;Wu D;Logsdon L;Mecsas J;Meydani SN
通讯作者：
Meydani SN
DOI：
10.1084/jem.20071019
发表时间：
2008-06-09
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Kranich J;Krautler NJ;Heinen E;Polymenidou M;Bridel C;Schildknecht A;Huber C;Kosco-Vilbois MH;Zinkernagel R;Miele G;Aguzzi A
通讯作者：
Aguzzi A